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Bilde av Ausbacher, Dominik
Bilde av Ausbacher, Dominik
Associate professor II Department of Pharmacy dominik.ausbacher@uit.no +4777646657 Tromsø

Dominik Ausbacher

Job description

Advising in assay implementation, assay data interpretation and new applications of antimicrobial and anticancer compounds developed at the Department of Pharmacy, UiT.

As pharmacist I see myself as communicator between different scientific fields with the ability to understand strengths and challenges of disciplines like chemistry, medicine or biology. This is important regarding drug optimization processes, where all three fields are tightly interconnected. My knowledge of different drug application/transport/targeting approaches can already in an early stage help to critically assess optimization processes and developmental strategies.

  • Dominik Ausbacher, Lindsey A. Miller, Darla M. Goeres, Philip S. Stewart, Morten Bøhmer Strøm, Adyary Fallarero :
    α,α-disubstituted β-amino amides eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal
    Biofilm 2023 ARKIV / DOI
  • Susannah von Hofsten, Manuel K Langer, Katja Korelin, Synnøve Norvoll Magnussen, Dominik Ausbacher, Trude Anderssen et al.:
    Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines
    Frontiers in Pharmacology 30. March 2023 ARKIV / DOI
  • Susannah von Hofsten, Marianne Hagensen Paulsen, Synnøve Magnussen, Dominik Ausbacher, Mathias Kranz, Annette Bayer et al.:
    The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines
    Scientific Reports 2022 ARKIV / DOI
  • Marianne Hagensen Paulsen, Magnus Engqvist, Dominik Ausbacher, Trude Anderssen, Manuel K- Langer, Tor Haug et al.:
    Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
    Journal of Medicinal Chemistry 2021 ARKIV / DOI
  • Jacobus Johannes Eksteen, Dominik Ausbacher, Terje Vasskog, Øystein Rekdal, John Sigurd Mjøen Svendsen :
    Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors
    ACS Omega 2020 ARKIV / DOI
  • Marianne Hagensen Paulsen, Dominik Ausbacher, Annette Bayer, Magnus Engqvist, Terkel Hansen, Tor Haug et al.:
    Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character
    European Journal of Medicinal Chemistry 2019 ARKIV / DOI
  • Marianne Hagensen Paulsen, Eskil Andre Karlsen, Dominik Ausbacher, Trude Anderssen, Annette Bayer, Philipp Ochtrop et al.:
    An amphipathic cyclic tetrapeptide scaffold containing halogenated β2,2-amino acids with activity against multi-resistant bacteria
    Journal of Peptide Science 2018 DOI
  • Dominik Ausbacher, Lindsey A. Lorenz, Betsey Pitts, Philip S. Stewart, Darla M. Goeres :
    Paired methods to measure biofilm killing and removal: a case study with Penicillin G treatment of Staphylococcus aureus biofilm
    Letters in Applied Microbiology 2017 ARKIV / DOI
  • Jacobus Johannes Eksteen, Dominik Ausbacher, Jaione Simon-Santamaria, Trine Stiberg, Cristiane de Albuquerque Cavalcanti Jacobsen, Imin Wushur et al.:
    Iterative design and in vivo evaluation of an oncolytic antilymphoma peptide
    Journal of Medicinal Chemistry 2016 DOI
  • Leena Hanski, Dominik Ausbacher, Terttu Tiirola, Morten B. Strøm, Pia M. Vuorela :
    Amphipathic β2,2-Amino Acid Derivatives Suppress Infectivity and Disrupt the Intracellular Replication Cycle of Chlamydia Pneumoniae
    PLOS ONE 09. June 2016 FULLTEKST / SAMMENDRAG / ARKIV / DOI
  • Marianne H. Paulsen, Magnus Engqvist, Dominik Ausbacher, Morten B. Strøm, Annette Bayer :
    Efficient and scalable synthesis of α,α-disubstituted β-amino amides
    Organic and biomolecular chemistry 2016 ARKIV / DOI
  • Annfrid Sivertsen, Veronika Tørfoss, Johan Isaksson, Dominik Ausbacher, Trude Anderssen, Bjørn Olav Brandsdal et al.:
    Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide binding to human serum albumin
    Journal of Peptide Science 2014 DOI
  • Dominik Ausbacher, Adyary Fallarero, Janni Kujala, Anni Määttänen, Jouko Peltonen, Morten B. Strøm et al.:
    Staphylococcus aureus biofilm susceptibility to small and potent β2,2-amino acid derivatives
    Biofouling (Print) 2014 DOI
  • Dominik Ausbacher, Gunbjørg Svineng, Terkel Hansen, Morten B. Strøm :
    Anticancer mechanisms of action of two small amphipathic beta(2,2)-amino acid derivatives derived from antimicrobial peptides
    Biochimica et Biophysica Acta - Biomembranes 19. July 2012 DOI
  • Veronika Tørfoss, Dominik Ausbacher, Cristiane de Albuquerque Cavalcanti Jacobsen, Terkel Hansen, Bjørn Olav Brandsdal, Martina Havelkova et al.:
    Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block
    Journal of Peptide Science 2012 DOI
  • Terkel Hansen, Dominik Ausbacher, Zack Georg Zachariassen, Trude Anderssen, Martina Havelkova, Morten B. Strøm :
    Anticancer activity of small amphipathic β2,2-amino acid derivatives
    European Journal of Medicinal Chemistry 2012 DOI
  • Veronika Tørfoss, Johan Isaksson, Dominik Ausbacher, Bjørn Olav Brandsdal, Gøril Eide Flaten, Trude Anderssen et al.:
    Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic b2,2-amino acid
    Journal of Peptide Science 2012 DOI
  • Terkel Hansen, Dominik Ausbacher, Gøril Eide Flaten, Martina Havelkova, Morten B. Strøm :
    Synthesis of Cationic Antimicrobial beta(2,2)-Amino Acid Derivatives with Potential for Oral Administration
    Journal of Medicinal Chemistry 2011 DOI
  • Stefan Hupfeld, Helene Moen, Dominik Ausbacher, Heinrich Haas, Martin Brandl :
    Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid
    Chemistry and Physics of Lipids 2010 DOI
  • Stefan Hupfeld, Dominik Ausbacher, Martin Brandl :
    Asymmetric flow field-flow fractionation of liposomes: optimization of fractionation variables
    Journal of Separation Science 2009 DOI
  • Stefan Hupfeld, Dominik Ausbacher, Martin Brandl :
    Asymmetric flow field-flow fractionation of liposomes: 2. Concentration detection and adsorptive loss phenomena
    Journal of Separation Science 2009 DOI
  • Susannah von Hofsten, Marianne Hagensen Paulsen, Manuel K Langer, Synnøve Norvoll Magnussen, Dominik Ausbacher, Annette Bayer et al.:
    A Compound Inspired by Arctic Marine Animals Kills Cancer Cells in vitro and in vivo
    2022
  • Susannah von Hofsten, Synnøve Norvoll Magnussen, Dominik Ausbacher, Marianne Hagensen Paulsen, Annette Bayer, Morten B. Strøm et al.:
    The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death
    2020 ARKIV
  • Dominik Ausbacher :
    Exploiting innate antimicrobial defenses: Antimicrobial peptides and peptide antibiotics as templates for novel anti-infective therapeutics
    2018 OMTALE
  • Dominik Ausbacher :
    Exploiting innate antimicrobial defenses: Antimicrobial peptides and peptide antibiotics as templates for novel anti-infective therapeutics
    2017 PROSJEKT
  • Dominik Ausbacher, Lindsey A. Lorenz, Darla M. Goeres, Philip S. Stewart, Morten B. Strøm, Pia M. Vuorela et al.:
    Antimicrobial β2,2-amino acid derivatives eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal
    2016
  • Leena Hanski, Dominik Ausbacher, Morten B. Strøm, Pia M Vuorela :
    Impact of β2,2-amino acid derivatives, a novel class of Chlamydia pneumoniae inhibitors, on bronchial epithelium VEGF production.
    2016
  • Dominik Ausbacher :
    Exploiting innate antimicrobial defenses: Antimicrobial peptides and peptide antibiotics as templates for novel anti-infective therapeutics
    2016
  • Dominik Ausbacher :
    β2,2-amino acid derivatives developed from antimicrobial peptides: Biological activity and mechanism of action studies
    2015
  • Dominik Ausbacher :
    Antimicrobial and anticancer β2,2-amino acid derivatives: Peptide mimetics with potential for oral administration
    2015
  • Dominik Ausbacher :
    Exploiting innate antimicrobial defenses: Antimicrobial peptides (AMPs) as templates for novel anti-infective therapeutics
    2015
  • Dominik Ausbacher, Leena Hanski, Terttu Tiirola, Morten B. Strøm, Vuorela Pia :
    Anti-Chlamydia pneumoniae activity of β2,2- amino acid derivatives mimicking antimicrobial peptides
    2014
  • Adyary Fallarero, Malena Skogman, Vânia Moreira, Suvi Manner, Dominik Ausbacher, Reko Leino et al.:
    The challenges of discovering new anti-biofilm probes from a high-throughput screening (HTS) perspective
    2013
  • Leena Pohjala, Dominik Ausbacher, Morten B. Strøm, Pia M. Vuorela :
    Inhibition of Chlamydia pneumoniae infectivity by β-amino acid derivatives mimicking cationic antimicrobial peptides
    2012
  • Dominik Ausbacher, Janni Kujala, Pia M. Vuorela, Morten B. Strøm, Adyary Fallarero :
    Control of Staphylococcus aureus biofilm with highly active β2,2-amino acid derivatives
    2012
  • Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm :
    Mechanisms of cancer cell death induced by two novel cationic β-peptidomimetics
    2011
  • Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm :
    Mechanisms of cancer cell death induced by two novel cationic beta-peptidomimetics
    Biopolymers 2011
  • Terkel Hansen, Dominik Ausbacher, Martina Havelkova, Morten B. Strøm :
    Bactericidal activity of small β-peptidomimetics
    2010

    • The 50 latest publications is shown on this page. See all publications in Cristin here →

    Research interests

     

    Conference presentations

    9) Dominik Ausbacher; Lindsey A. Lorenz; Darla M. Goeres; Philip S. Stewart ; Morten B. Strøm; Pia M. Vuorela; Adyary Fallarero. Antimicrobial β2,2-amino acid derivatives eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal. DPhG Annual Meeting, Munich (2016).

    8) Leena Hanski, Dominik Ausbacher; Morten B. Strøm; Pia M. Vuorela. Impact of β2,2-amino acid derivatives, a novel class of Chlamydia pneumoniae inhibitors, on bronchial epithelium VEGF production. Conference on Lung and Respiratory Care, Manchester (2016).

    7) Adyary Fallarero, Malena Skogman, Vânia Moreira, Suvi Manner, Dominik Ausbacher, Reko Leino, Morten B. Strøm, Jari Yli-Kauhaluoma, Pia M. Vuorela. The challenges of discovering new anti-biofilm probes from a high-throughput screening (HTS) perspective. Eurobiofilms 2013 - 3rd European Congress on Microbial Biofilms - Basic and Clinical Aspects, Ghent (2013).

    6) Leena Pohjala, Dominik Ausbacher, Morten B. Strøm, Pia M. Vuorela. Inhibition of Chlamydia pneumoniae infectivity by β-amino acid derivatives mimicking cationic antimicrobial peptides. 7th meeting of the European society for Chlamydia research, Amsterdam (2012).

    5) Dominik Ausbacher, Janni Kujala, Pia M. Vuorela, Morten B. Strøm, Adyary Fallarero. Control of Staphylococcus aureus biofilm with highly active β2,2-amino acid derivatives. 3rd International Symposium on Antimicrobial Peptides, Lille (2012).

    4) Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm. Mechanisms of cancer cell death induced by novel cationic β-peptidomimetics. 22nd American Peptide Symposium, San Diego (2011).

    3) Terkel Hansen, Dominik Ausbacher, Martina Havelkova, Morten B. Strøm. Bactericidal activity of small β-peptidomimetics. 31. European Peptide Symposium, Copenhagen (2010).

    2) Veronika Tørfoss, Dominik Ausbacher, Terkel Hansen, Martina Havelkova, Morten B. Strøm Anticancer activity of small cationic β-peptidomimetics. 31. European Peptide Symposium, Copenhagen (2010).

    1) C. Becker, A. Ehmer, A. Maschke, A. Meindorfer, D. Ausbacher, J. Tessmar, T. Blunk, A. Goepferich. Influence of Micronisation of Proteins on the Properties of Lipid Microparticles for Controlled Release. DPhG Joint Meeting, Marburg (2006).

     

    Publications

    19) von Hofsten, S; Paulsen, M.H.; Magnussen, S.N.; Ausbacher, D.; Kranz, M.; Bayer, A.; Strøm, M.B., Berge, G. (2022).  The marine natural product mimi MPM‑1 is cytolytic and induces DAMP release from human cancer cell lines, Scientific Reports. 12:15586. DOI: 10.1038/s41598-022-19597-4

    18) Paulsen, M.P.; Engqvist, M.; Ausbacher, D.; Anderssen T.; Langer, M.K.; Haug, T. Morello, G.R.;  Liikanen, L.E.; Blencke, H-M.; Isaksson, J.; Juskewitz, E. Bayer, A.; Strøm, M.B. (2021). Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates, J. Med Chem. 64: 11395–11417. DOI: 10.1021/acs.jmedchem.1c00734

    17) Eksteen, J. J.; Ausbacher, D.; Vasskog, T.; Rekdal, Ø.; Svendsen, J. S. M. (2020). Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors. ACS Omega DOI: 10.1021/acsomega.9b00700

    16) Paulsen, M.H.; Ausbacher, D.; Bayer, A.; Engqvist, M; Hansen, T.; Haug, T.; Anderssen, T.; Andersen, J.H.; Ericson Sollid J.U.; Strøm, M.B. (2019). Antimicrobial activity of amphipathic α, α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character. European Journal of Medicinal Chemistry. DOI: 10.1016/j.ejmech.2019.111671

    15) Paulsen, M.H.; Karlsen, E.A.; Ausbacher, D.; Anderssen, T.; Bayer, A.; Ochtrop, P.; Hedberg, C.; Haug, T.; Ericson Sollid, J.U.; Strøm M.B. (2018). An amphipathic 13-membered cyclic tetrapeptide scaffold containing β2,2-amino acids with activity against multi-resistant bacteria. Journal of Peptide Science. DOI: 10.1002/psc.3117

    14) Ausbacher, D; Lorenz, L.A.; Pitts, B.; Stewart, P.S.; Goeres, D.M. (2017). Paired methods to measure biofilm killing and removal: a case study with Penicillin G treatment of Staphylococcus aureus biofilm. Letters in Applied Microbiology. DOI: 10.1111/lam.12843

    13) Eksteen, J.J.; Ausbacher, D.; Simon-Santamaria, J.; Stiberg, T.; Cavalcanti-Jacobsen, C.; Wushur, I.; Svendsen, J.S.; Rekdal, Ø. (2016). Iterative Design and in Vivo Evaluation of an Oncolytic Antilymphoma Peptide. Journal of Medicinal Chemistry. DOI: 10.1021/acs.jmedchem.6b00839.

    12) Paulsen, M.H.; Engqvist, M.; Ausbacher, D.; Strøm, M. B.; Bayer, A. (2016). Efficient and scalable synthesis of α,α-­disubstituted β-amino amides. Organic and biomolecular chemistry . ISSN 1477-0520.s DOI: 10.1039/C6OB01219A

    11) Hanski, L.#; Ausbacher, D.#; Tiirola, T.M.; Strøm, M.B.; Vuorela, P.M. (2016). Amphipathic β2,2-amino acid derivatives suppress infectivity and Ddsrupt the intracellular replication cycle of Chlamydia pneumoniae. PLoS ONE, 11(6). DOI: 10.1371/journal.pone.0157306 #contributed equally

    10) Sivertsen, A.; Tørfoss, V.; Isaksson, J.; Ausbacher, D.; Anderssen, T.; Brandsdal, B. O.; Havelkova, M.; Skjørholm, A. E.; Strøm M.B. (2013). Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide-binding to human serum albumin. J. Pept. Sci., 20: 279-291.

    9) Ausbacher, D.; Fallarero, A.; Kujala, J.; Määttänen, A; Jouko, Peltonen; Strøm, M.B.; Vuorela, P.M. (2014). Staphylococcus aureus biofilm susceptibility to small and potent β2,2-amino acid derivatives. Biofouling, 30: 81-93. DOI: 10.1080/08927014.2013.847924

    8) Ausbacher, D.; Svineng, G.; Hansen, T.; Strøm M.B. (2012). Anticancer mechanisms of action of two small amphipathic β2,2-amino acid derivatives derived from antimicrobial peptides. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818: 2917-2925. DOI: 10.1016/j.bbamem.2012.07.005

    7) Hansen, T.; Ausbacher, D.; Zachariassen, Z.G.; Anderssen, T.; Havelkova, M.; Strøm M.B. (2012) Anticancer activity of small amphipathic β2,2-amino acid derivatives, European Journal of Medicinal Chemistry, 58: 22-29.

    6) Tørfoss, V.; Isaksson, J.; Ausbacher, D.; Brandsdal, B. O.; Flaten, G. E.; Anderssen, T.; Cavalcanti-Jacobsen, C. de A.; Havelkova, M.; Nguyen, L. T.; Vogel, H. J.; Strøm, M. B. (2012) Improved anticancer potency by head-to-tail cyclisation of short cationic anticancer peptides containing a lipophilic β2,2-amino acid, Journal of Peptide Science, 18: 609-619.

    5) Tørfoss, V.; Ausbacher, D.; Cavalcanti-Jacobsen, C.deA.; Hansen, T.; Brandsdal, B-.O.; Havelkova, M.; Strøm, M.B. (2011): Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block, Journal of Peptide Science 18: 170-176.

    4) Hansen, T.; Ausbacher, D.; Flaten, G. E.; Havelkova, M.; Strøm, M. B.(2011): Synthesis of cationic antimicrobial β2,2-amino acid derivatives with potential for oral administration, Journal of Medicinal Chemistry 54: 858-868.

    3) Hupfeld, S.; Moen, H. H.; Ausbacher, D.; Haas, H.; Brandl, M. (2010): Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid. Chemistry and Physics of Lipids 163: 141-147.

    2) Hupfeld, S.; Ausbacher, D.; Brandl, M. (2009): Asymmetric flow field-flow fractionation of liposomes: 2. Concentration-detection and adsorptive loss phenomena. Journal of Separation Science 32: 3555-3561.

    1) Hupfeld, S.; Ausbacher, D.; Brandl, M. (2009): Asymmetric flow field-flow fractionation of liposomes: optimization of fractionation variables. Journal of Separation Science 32: 1465-1470.

     

    Patent

    Strøm M.B., Bayer A., Engquvist M.S.O., Paulsen M.H., Ausbacher, D. (2018). Barbituric acid derivatives comprising cationic and lipophilic groups. US11072588B2/en

     

    Stipends

    Personal overseas research grant of the Research Council of Norway (2014/15)

    UiT transition grant for recruitment of young researchers (2012/13)

    UiT mobility grant for research abroad (2011)

    Travel grant of the Norwegian Pharmaceutical Society (2011)

     

    Studies and Education

    09/2015 - 02/2017
    Postdoc, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group, Prof. M. B. Strøm, UiT-The Arctic University of Norway

    03/2015 - 08/2015
    Postdoc, Center for Biofilm Engineering, Standardized Biofilm Methods Laboratory, Assistant Prof. D. Goeres and Biofilm Control Laboratory, Prof. P.Stewart, Montana State University, Bozeman, USA


    09/2014 - 02/2015
    Postdoc, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, Anti-infective Research Laboratory, Adjunct Prof. A. Fallarero and Prof. P. Vuorela, University of Helsinki, Finland


    03/2013 - 08/2014
    Postdoc, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group, Prof. M. B. Strøm, UiT-The Arctic University of Norway

    11/2012 - 02/2013
    Researcher, Faculty of Health Sciences, UiT-The Arctic University of Tromsø

    11/2012
    PhD thesis defence: Biological activity of β2,2-amino acid derivatives derived from antimicrobial peptides- Investigations of Antimicrobial and Anticancer Activity and the Mechanisms of Action

    11/2011 - 02/2012
    Visiting PhD student, Pharmacutical Sciences Laboratory, Prof. P. Vuorela, Åbo Akademi University, Turku, Finland


    10/2008 - 09/2012
    Ph.D. student, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group Prof. M. B. Strøm, UiT-The Arctic University of Norway

    07/2008 and 12/2012
    Licensure for the profession as pharmacist in Germany and Norway

    10/2007
    Diploma defence, A4F/MALS Analysis of Liposomes, Faculty of Biosciences, Department of Pharmaceutical Technology Prof. K. Mäder, University of Halle, Germany

    05/2007 - 10/2007
    Diploma student, Faculty of Health Sciences, Drug Transport and Delivery Research Group Prof. M. Brandl, UiT-The Arctic University of Norway

    04/2007
    Second State Exam

    08/2004
    First State Exam

    10/2002 - 04/2007
    Pharmacy studies, University of Regensburg, Germany

    06/2001
    Karlsgymnasium Bad Reichenhall, University-entrance diploma

     

    Languages

    German (native)
    English
    Norwegian

     

    Work experience

    09/2008
    Researcher for Epitarget AS, Oslo

    11/2007 - 04/2008
    Pharmacist in practical training, Ahorn Apotheke, Regensburg

    09/2006 - 10/2006
    Aenova Sales Pharma - Dragenopharm-Apotheker Püschel GmbH & Co. KG, Tittmoning

    07/2001 - 06/2002
    Service in the mountain infantry batallion Berchtesgaden, Armed forces of Germany

     

     
    Researcher profile in Cristin
    ResearchGate