Disputas Cand. Med Benjamin Stage Storm

Storm disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:

“Venous Air Embolism and Complement-driven Thromboinflammation.  In vitro human whole blood studies and in vivo porcine studies on the effect of air emboli on the complement system, cytokine network, and the hemostasis”

Avhandlingen er tilgjengelig her!

The doctoral thesis!

 

Prøveforelesning starter  kl. 10.15:

Prøveforelesningen har følgende tittel: «Complement inhibitors in intensive care medicine - current knowledge and future possibilities»

Prøveforelesningen vil bli strømmet/ The trial lecture will be streamed!

 

Disputasen starter 12.15

Disputasen vil bli strømmet/ the defence will be streamed!

Opptak av disputasen vil være tilgjengelig i et døgn./ A recording of the disputation will be available for 24 hours.

Auditoriet er åpent for publikum, men vil også bli strømmet.

 

Populærvitenskapelig sammendrag av avhandlingen:

Air bubbles entering the blood circulation may complicate medical procedures, potentially resulting in hemodynamic collapse, organ infarctions, or death. Air bubbles trigger inflammation and coagulation, mainly by activating a part of the immune system known as the complement system. However, the exact mechanisms are not fully elucidated, and no specific treatment for air-induced inflammation exists. This project examined the effect of ambient air and air bubbles on the thrombo-inflammatory system in human whole blood in test tubes and in pigs. We found that avoiding ambient air in test tubes during experiments significantly reduced “unavoidable” complement and coagulation background activation. Air activated a key complement molecule, C3, in a unique manner seldom seen in other inflammatory conditions. C3 inhibition attenuated both inflammation and coagulation but not platelet activation, pointing towards C3 inhibitions as a potential therapy in patients with air-induced inflammation.

Hovedveileder

Professor Tom Erik Mollnes, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Biveiledere

Professor II Erik Waage Nielsen, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Bedømmelseskomité

Professor Seppo Meri, University of Helsinki - 1. opponent.

Seniorforsker Inkeri Lokki, University of Helsinki - 2. opponent.

Førsteamanuensis Eirik Hugaas Ofstad, Institutt for samfunnsmedisin, UIT, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder: Professor Knut Tore Lappegård, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

When: 27. September 2022 at 10.15–15.15
Where: Nordlandssykehuset Bodø, auditoriet 9 etasje somatikk, sentrum
Location / Campus: Digital
Target group: Employees, Students, Guests, Invited
Contact: Guro Pedersen
E-mail: guro.pedersen@uit.no
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