Disputas-Cand.med Trym Thune Flygel

Prøveforelesning over oppgitt emne holdes kl. 11:15, samme sted

“Adolescents growing up with HIV: Outcomes, obstacles, and opportunities for the future”

Populærvitenskapelig sammendrag av avhandlingen:

HIV-associated chronic lung disease is the most prevalent comorbidity among children and adolescents with HIV in sub-Saharan Africa. HIV causes a disrupted gut barrier and gut microbial dysbiosis. This can lead to systemic immune activation, thought to contribute to the development of HIV-associated comorbidities. We investigated the composition of gut microbiota and studied the effects of antibiotic treatment on gut microbial composition and lung inflammation among children and adolescents with HIV-associated chronic lung disease in Zimbabwe and Malawi.

Participants with HIV had reduced gut microbial diversity compared to HIV negative, but diversity improved with antiretroviral therapy. The antibiotic azithromycin reduced gut microbial diversity, but these changes did not persist 6 months after cessation of antibiotics. Exhaled nitric oxide, a measure of local inflammation in the lungs, was associated with acute respiratory exacerbations and biomarkers of inflammation.

This work highlights the association between HIV and gut microbial dysbiosis and the effect of long-term antibiotics on lung inflammation and composition of gut microbiota. It can be helpful when designing new studies on gut microbiota and potential microbiota-related targets for interventions in the future.

Hovedveileder

Professor emeritus Trond Flægstad, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Biveileder

Førsteamanuensis Jorunn Pauline Cavanagh, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Ph.d. Evgeniya Sovershaeva, Akershus Universitetssykehus og UNN

Forsker Erik Hjerde, Institutt for kjemi, Fakultet for naturvitenskap og teknologi, UiT Norges arktiske universitet

Bedømmelseskomité

Professor Marius Trøseid, Institutt for indremedisinsk forskning, Universitetet i Oslo - 1. opponent

Forsker Sabrina Moyo, Klinisk institutt 2, Universitetet i Bergen – 2. opponent

Professor Maja-Lisa Løchen, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet - leder av komité

Disputasleder: Professor Inigo Z Martinez, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Flygel disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen: “HIV Infected African Children: Gut microbiota in relation to chronic lung disease and long-term antibiotic treatment”

Flygel disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:

“HIV Infected African Children: Gut microbiota in relation to chronic lung disease and long-term antibiotic treatment”