Disputas - Cand. med. Synnøve Magnhild Jensen

Avhandlingen er tilgjengelig her! / The doctoral thesis is available here!


Auditoriet er åpent for publikum. Disputasen strømmes og et opptak vil være tilgjengelig i et døgn.
The auditorium is open to the public. The defense will still be streamed, and a recording of the disputation will be available for 24 hours.


Prøveforelesning over oppgitt emne starter kl. 09.15 / The trial lecture starts at 09.15
Tittel/Title: «Diagnostikk av nevromuskulære sykdommer»
Prøveforelesningen strømmes her / The trial lecture will be streamed here.

Disputasen starter kl. 11.15 / The defense starts at 11.15
Disputasen strømmes her / The defense will be streamed here


Populærvitenskapelig sammendrag av avhandlingen/ Summary of the thesis

Limb-girdle muscular dystrophy R9 (LGMDR9) is a rare hereditary muscle disease.
This work explores the spread of LGMDR9 in Norway, natural history, and quality of life (QoL) and sleep disorders in the Norwegian LGMDR9 population. Individuals with LGMDR9 were identified through the hospitals. Questionnaires and patient notes were collected from consenting persons. Adults were also invited to a battery of tests. A total of 153 individuals were identified. The density was highest in Northern and Central Norway – up to 8.3/100,000, which is the highest recorded worldwide.
The results indicate sex differences in natural history. Both physical, mental and social health aspects of QoL were impaired. Fatigue showed particular importance in relation to QoL and was frequent, suggesting a need for improved identification and treatment. Sleep disorders (insomnia and sleep apnea) appear to be underrecognized. The findings provide relevant information to clinical care and clinical trials for LGMDR9.

Veiledere/ Supervisors:
Hovedveileder/Main supervisor:
Førsteamanuensis Kjell Arne Arntzen, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

Biveiledere/supervisors:
Førsteamanuensis Kai Ivar Müller[CMK1] , Nevrologisk avdeling Sørlandet sykehus, Kristiansand.
Professor emeritus Svein Ivar Mellgren, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

Bedømmelseskomité/Defensecomitee:
Professor Bjarne Udd, Tampere Neuromuscular Center, Tampere University and Hospital – 1. opponent.
Ph.d. Trine Haug Popperud, Nevrologisk avdeling Oslo Universitetssykehus – 2. opponent.
Ph.d. Maria Kristin Carlsson, Institutt for klinisk medisin, UiT Norges arktiske universitet – leder av komité.

Disputasleder/ Leader of defense:
Professor Brita Elvevåg, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.