KJE-3201 Bioinorganic Chemistry - 10 ECTS
Admission requires a Bachelor`s degree (180 ECTS) in Chemistry or equivalent. A thorough knowledge of elementary university-level organic and inorganic chemistry, corresponding to a grade of C or better in KJE-1002 and KJE-1004, will be assumed, as will a modest exposure to elementary biochemistry and NMR spectroscopy. A reasonable knowledge of elementary ligand field theory and organic reaction mechanisms will be assumed
Local admission, application code 9371 - singular courses at Master's level.
The student should acquire the following knowledge, skills and competencies.
- A broad knowledge of metalloprotein active sites and metal-containing cofactors and of metal-nucleic-acid interactions, as outlined in a standard textbook;
- A detailed mechanistic knowledge of iron- and copper-containing enzymes involved in dioxygen metabolism;
- A detailed mechanistic knowledge of specialized cofactors including iron-sulfur clusters, cobalamin, and molybdopterin;
- Geometric and electronic-structural aspects of metal-NO interactions;
- Aspects of metals in medicine, such as platinum anticancer drugs and technetium radiopharmaceuticals;
- Aspects of environmental bioinorganic chemistry, such as arsenic toxicity
- Have a convincing command of the basic facts of bioinorganic chemistry, particularly the major classes of metalloenzymes,
- Ability to describe and discuss the geometric and electronic structures of bioinorganic systems in terms of ligand field theory;
- Above all, to be able to propose and test mechanistic hypotheses for a wide range of metalloenzymes and model systems.
- To "think on one's feet" about the electronic structures and mechanisms of metalloenzymes and their synthetic models;
- To be able to read the current bioinorganic literature and appreciate it from a mechanistic perspective.
This course is open for inbound exchange student who meets the admission requirements, including prerequisites. Please see the Admission requirements" and the "Prerequisite" sections for more information.
Do you have questions about this module? Please check the following website to contact the course coordinator for exchange students at the faculty: https://en.uit.no/education/art?p_document_id=510412
|A–E, fail F
To take an examination, the student must have passed the following coursework requirements:
|Passed written report/literature review
|Approved – not approved
- About the course
- Campus: Tromsø |
- ECTS: 10
- Course code: KJE-3201
- Responsible unit
- Department of Chemistry
- Earlier years and semesters for this topic