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Bilde av Geiseler, Samuel
Bilde av Geiseler, Samuel
Associate professor Department of Medical Biology samuel.geiseler@uit.no +4777644247 +47 776 44247 You can find me here

Samuel Geiseler

Job description

Associate professor in the establishment phase. 50/50 teaching and research. 

  • Samuel Jakob Geiseler, Alena Hadzic, Marvin Lambertus, Karl Martin Forbord, Ghazal Sajedi, Arthur Liesz et al.:
    L-Lactate Treatment at 24 h and 48 h after Acute Experimental Stroke Is Neuroprotective via Activation of the L-Lactate Receptor HCA1
    International Journal of Molecular Sciences 2024 DOI
  • Nadia Skauli, Negar Zohoorian Izadpanah, Shervin Banitalebi, Samuel Jakob Geiseler, Maher Salameh, Rao Shreyas et al.:
    Aquaporin-4 deletion leads to reduced infarct volume and increased peri-infarct astrocyte reactivity in a mouse model of cortical stroke
    Journal of Physiology 2024 ARKIV / DOI
  • Samuel Jakob Geiseler, Kimberly Dungdung Phan, Camilla Brox, Teresa Dang Nguyen, Can Hicabi Tartanoglu, Hanne Lise Doosje et al.:
    Pre-stroke exercise does not reduce atrophy in healthy young adult mice
    Neuroscience Letters 2023 ARKIV / DOI
  • Shervin Banitalebi, Nadia Skauli, Samuel Geiseler, Ole Petter Ottersen, Mahmood Amiry-Moghaddam :
    Disassembly and Mislocalization of AQP4 in Incipient Scar Formation after Experimental Stroke
    International Journal of Molecular Sciences 2022 ARKIV / DOI
  • Marvin Lambertus, Linda Thøring Øverberg, Krister Andreas Andersson, Malin Sørli Hjelden, Alena Hadzic, Øyvind Pernell Haugen et al.:
    L‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA1
    Acta Physiologica 26. November 2020 ARKIV / DOI
  • Samuel Geiseler, Cecilie Morland :
    The janus face of VEGF in stroke
    International Journal of Molecular Sciences 2018 ARKIV / DOI
  • Samuel Geiseler, John Larson, Lars Folkow :
    Synaptic transmission despite severe hypoxia in hippocampal slices of the deep-diving hooded seal
    Neuroscience 2016 DOI
  • Samuel Geiseler, Stian Ludvigsen, Lars Folkow :
    KATP-channels play a minor role in the protective hypoxic shut-down of cerebellar activity in eider ducks (Somateria mollissima)
    Neuroscience 2015 DOI
  • Nicole Czech-Damal, Samuel Geiseler, MLM Hoff, R Schliep, Jan-Marino Ramirez, Lars Folkow et al.:
    The role of glycogen, glucose and lactate in neuronal activity during hypoxia in the hooded seal (Cystophora cristata) brain
    Neuroscience 2014 DOI
  • Samuel Geiseler, Arnoldus Schytte Blix, Jennifer M. Burns, Lars Folkow :
    Rapid postnatal development of myoglobin from large liver iron stores in hooded seals
    Journal of Experimental Biology 2013 DOI
  • Sandra Núῆez-Egido, Samuel Jakob Geiseler, Lars P. Folkow, Ole-Jakob How :
    Mitochondria bioenergetics; diving vs non-diving mammals
    2022
  • Håkon Olsen, Lorena Arranz, Samuel Jakob Geiseler :
    Characterization of the bone marrow microenvironment in succinate receptor knock-out mice
    UiT Norges arktiske universitet 2021
  • Samuel Geiseler, Alena Hadzic, Ghazal Sajedi, Karl Martin Frøseth Forbord, Cecilie Morland :
    Lactate injections are neuroprotective in stroke via HCAR1
    2020
  • Camilla Brox, Cecilie Morland, Samuel Geiseler :
    Lactate receptor HCAR1 in the protection against neuroinflammation in stroke
    Universitetsforlaget 2020
  • Kimberly Dungdung Phan, Samuel Geiseler, Cecilie Morland :
    The lactate receptor HCAR1 in the regulation of neurogenesis and angiogenesis during stroke
    Universitetsforlaget 2020
  • Lorenzo Ragazzi, Samuel Geiseler, Lars Folkow :
    Efflux of neurotransmitters from brain Slices during O2 deprivation - comparing diving and non-diving species
    Acta Physiologica 2014
  • Lorenzo Ragazzi, Samuel Geiseler, Lars Folkow :
    POSTER: Efflux of neurotransmitter from brain slices during O2 deprivation - comparing diving and non-diving species
    2014
  • Samuel Geiseler, John Larson, Lars Folkow :
    In vitro synaptic responses in hippocampal Slices from hooded seals (Cystophora cristata)
    Acta Physiologica 2014
  • Samuel Geiseler :
    Can seals help us treat stroke damage?
    Nansen NEuroscience Network 2014
  • Samuel Geiseler, Lars Folkow, John Larson :
    ORAL: In vitro synaptic responses in hippocampal slices from hooded seals (Cystophora cristata)
    2014
  • Samuel Geiseler, Arnoldus Schytte Blix, JM Burns, Lars Folkow :
    Rapid postnatal development of myoglobin is supported by liver iron stores in hooded seal pups
    Acta Physiologica 2012

    • The 50 latest publications is shown on this page. See all publications in Cristin here →

    Research interests

    Stroke is one of the most common causes for premature human death in the western world. The dominant physiological damage in stroke is due to the reduction/stop of bloodflow (e.g. in the brain or heart) and the resulting lack oxygen (ischemia). This in turn leads to insufficient cellular energy production resulting in tissue damage, often leading to physical disabiltity or death.
    However, a number of animals can tolerate very low levels of oxygen (hyoxia) for long periods of time without any physiological damage. I am investigating what kind of adaptations their bodies have developed to withstand hypoxia. Current animal models are deep diving seals and hibernating hamsters. Both are able to dramatically reduce their physiological activity to save energy, i.e. they go (partially) in a type of "standby mode" to avoid depleeting their energy storages during hypoxia. I am investigating mechanisms how this reduction in activiy is controlled. 
    The overarching goal with such comparative research is to develop better treatments to treat stroke patients. 

    Researcher profile in Cristin
    ORCID: https://orcid.org/0000-0002-1332-3816

    Member of research group

    Cardiovascular Research Group   English content

    Member of project

    Bachelor and Master projects