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Department of Medical Biology erik.knutsen@uit.no +4777620899 48201910 Tromsø MH L8.231

Erik Knutsen


Researcher


  • Tellez Gabriel, Marta; Tekpli, Xavier; Reine, Trine M.; Hegge, Beate; Nielsen, Stephanie Rose; Chen, Meng; Moi, Line; Normann, Lisa Svartdal; Rasmussen Busund, Lill-Tove; Calin, George A.; Mælandsmo, Gunhild Mari; Perander, Maria; Theocharis, Achilleas D.; Kolset, Svein Olav; Knutsen, Erik. Serglycin is Involved in TGF-β induced epithelial-mesenchymal transition and is highly expressed by immune cells in breast cancer tissue. Frontiers in Oncology 2022; Volum 12:868868. ISSN 2234-943X.s 1 - 13.s doi: 10.3389/fonc.2022.868868.
  • Emblem, Åse; Knutsen, Erik; Jørgensen, Tor Erik; Fure, Hilde; Johansen, Steinar Daae; Brekke, Ole Lars; Mollnes, Tom Eirik; Karlsen, Bård Ove. Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene. Non-coding RNA 2022; Volum 8 (2). ISSN 2311-553X.s doi: 10.3390/ncrna8020024.
  • Rosenlund, Ingrid A; Calin, George A.; Dragomir, Mihnea Paul; Knutsen, Erik. CRISPR/Cas9 to Silence Long Non-Coding RNAs. Springer 2021 ISBN 978-1-0716-1580-5.
  • Brun, Vegard Heimly; Knutsen, Erik; Stenvold, Helge; Halvorsen, Hanne. Severe hypercalcemia caused by parathyroid hormone in a rectal cancer metastasis: a case report. BMC Endocrine Disorders 2021; Volum 21:4. ISSN 1472-6823.s 1 - 6.s doi: 10.1186/s12902-020-00664-8.
  • Zambalde, Erika Pereira; Bayraktar, Recep; Jucoski, Tayana Schultz; Ivan, Cristina; Rodrigues, Ana Carolina de Mello Alves; Mathias, Carolina; Knutsen, Erik; Silveira de Lima, Rubens; Gradia, Daniela Fiori; Fonseca, Enilze Maria de Souza; Hannash, Samir; Calin, George A.; Oliveira, Jaqueline Carvalhode. A novel lncRNA derived from an ultraconserved region: lnc- uc.147, a potential biomarker in luminal A breast cancer. RNA Biology 2021; Volum 18 (1). ISSN 1547-6286.s 416 - 429.s doi: 10.1080/15476286.2021.1952757.
  • Dragomir, Mihnea Paul; Knutsen, Erik; Calin, George A.. Classical and noncanonical functions of miRNAs in cancers. Trends in Genetics 2021. ISSN 0168-9525.s doi: 10.1016/j.tig.2021.10.002.
  • Knutsen, Erik; Harris, Adrian; Perander, Maria. Expression and functions of long non-coding RNA NEAT1 and isoforms in breast cancer. British Journal of Cancer 2021. ISSN 0007-0920.s doi: 10.1038/s41416-021-01588-3.
  • Manaila, Roxana; Moisoiu, Vlad; Knutsen, Erik; Dragomir, Mihnea-Paul; Calin, George A. Diagnostic and Therapeutic MicroRNAs in Primary Myelofibrosis. Proceedings of the Singapore National Academy of Science 2020. ISSN 2591-7226.s doi: 10.1142/S2591722620400074.
  • Chen, Baoqing; Dragomir, Mihnea Paul; Fabris, Linda; Bayraktar, Recep; Knutsen, Erik; Liu, Xu; Tang, Changyan; Li, Yongfeng; Shimura, Tadanobu; Ivkovic, Tina Catela; Cruz De los Santos, Mireia; Anfossi, Simone; Shimizu, Masayoshi; Shah, Maitri Y.; Ling, Hui; Shen, Peng; Multani, Asha S.; Pardini, Barbara; Burks, Jared K.; Katayama, Hiroyuki; Reineke, Lucas C.; Huo, Longfei; Syed, Muddassir; Song, Shumei; Ferracin, Manuela; Oki, Eiji; Fromm, Bastian; Ivan, Cristina; Bhuvaneshwar, Krithika; Gusev, Yuriy; Mimori, Koshi; Menter, David; Sen, Subrata; Matsuyama, Takatoshi; Uetake, Hiroyuki; Vasilescu, Catalin; Kopetz, Scott; Parker-Thornburg, Jan; Taguchi, Ayumu; Hanash, Samir M.; Girnita, Leonard; Slaby, Ondrej; Goel, Ajay; Varani, Gabriele; Gagea, Mihai; Li, Chunlai; Ajani, Jaffer A.; Calin, George A.. The long noncoding RNA CCAT2 induces chromosomal instability through BOP1-AURKB signaling. Gastroenterology 2020; Volum 159 (6). ISSN 0016-5085.s 2146 - 2162.s doi: 10.1053/j.gastro.2020.08.018.
  • Tellez Gabriel, Marta; Knutsen, Erik; Perander, Maria. Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies. International Journal of Molecular Sciences 2020. ISSN 1661-6596.s doi: 10.3390/ijms21249457.
  • Dragomir, Mihnea Paul; Moisoiu, Vlad; Manaila, Roxana; Pardini, Barbara; Knutsen, Erik; Anfossi, Simone; Amit, Moran; Calin, George A. A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment. Journal of Clinical Medicine 2020. ISSN 2077-0383.s doi: 10.3390/jcm9113529.
  • Dragomir, Mihnea Paul; Manyam, Ganiraju C; Ott, Leonie Florence; Berland, Léa; Knutsen, Erik; Ivan, Cristina; Lipovich, Leonard; Broom, Bradley M.; Calin, George A. FuncPEP: A Database of Functional Peptides Encoded by Non-Coding RNAs. Non-coding RNA 2020. ISSN 2311-553X.s doi: 10.3390/ncrna6040041.
  • Amit, Moran; Takahashi, Hideaki; Dragomir, Mihnea Paul; Lindemann, Antje; Gleber-Netto, Frederico O.; Pickering, Curtis R.; Anfossi, Simone; Osman, Abdullah A.; Cai, Yu; Wang, Rong; Knutsen, Erik; Shimizu, Masayoshi; Ivan, Cristina; Rao, Xiayu; Wang, Jing; Silverman, Deborah A.; Tam, Samantha; Zhao, Mei; Caulin, Carlos; Zinger, Assaf; Tasciotti, Ennio; Dougherty, Patrick M.; El-Naggar, Adel; Calin, George A; Myers, Jeffrey N.. Loss of p53 drives neuron reprogramming in head and neck cancer. Nature 2020; Volum 578. ISSN 0028-0836.s doi: 10.1038/s41586-020-1996-3.
  • Fuentes-Mattei, Enrique; Bayraktar, Recep; Manshouri, Taghi; Silva, Andreia M; Ivan, Cristina; Gulei, Diana; Fabris, Linda; do Amaral, Nayra Soares; Mur, Pilar; Perez, Cristina; Torres-Claudio, Elizabeth; Dragomir, Mihnea Paul; Badillo-Perez, Adriana; Knutsen, Erik; Narayanan, Pranav; Golfman, Leonard; Shimizu, Masayoshi; Zhang, Xinna; Zhao, Wanke; Ho, Wanting Tina; Estecio, Marcos Roberto; Bartholomeusz, Geoffrey; Tomuleasa, Ciprian; Berindan-Neagoe, Ioana; Zweidler-McKay, Patrick A.; Estrov, Zeev; Zhao, Zhizhuang J.; Verstovsek, Srdan; Calin, George A.; Redis, Roxana S.. MiR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2. JCI Insight 2020; Volum 5 (1). ISSN 2379-3708.s 1 - 19.s doi: 10.1172/jci.insight.121781.
  • Knutsen, Erik; Lellahi, Seyed Mohammad; Aure, Miriam Ragle; Nord, Silje; Fismen, Silje; Larsen, Kenneth Bowitz; Tellez Gabriel, Marta; Hedberg, Annica; Bjørklund, Sunniva; Bofin, Anna M.; Mælandsmo, Gunhild Mari; Sørlie, Therese; Mortensen, Elin Synnøve; Perander, Maria. The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers. Scientific Reports 2020; Volum 10:1277. ISSN 2045-2322.s 1 - 14.s doi: 10.1038/s41598-020-57759-4.
  • Pichler, Martin; Rodriguez-Aguayo, Cristian; Nam, Su Youn; Dragomir, Mihnea Paul; Bayraktar, Recep; Anfossi, Simone; Knutsen, Erik; Ivan, Cristina; Fuentes-Mattei, Enrique; Lee, Sang Kil; Ling, Hui; Catela Ivkovic, Tina; Huang, Guoliang; Huang, Li; Okugawa, Yoshinaga; Katayama, Hiroyuki; Taguchi, Ayumu; Bayraktar, Emine; Bhattacharya, Rajat; Amero, Paola; He, William Ruixian; Tran, Anh M.; Vychytilova-Faltejskova, Petra; Klec, Christiane; Bonilla, DIana L.; Zhang, Xinna; Kapitanovic, Sanja; Loncar, Bozo; Gafà, Roberta; Wang, Zhihui; Cristini, Vittorio; Hanash, Samir M.; Bar-Eli, Menashe; Lanza, Giovanni; Slaby, Ondrej; Goel, Ajay; Rigoutsos, Isidore; Lopez-Berestein, Gabriel; Calin, George Adrian. Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer. Gut 2020; Volum 69. ISSN 0017-5749.s 1 - 14.s doi: 10.1136/gutjnl-2019-318903.
  • Braicu, Cornelia; Gulei, Diana; Cojocneanu, Roxana Maria; Raduly, Lajos; Jurj, Ancuta; Knutsen, Erik; Calin, George Adrian; Berindan-Neagoe, Ioana. miR-181a/b therapy in lung cancer: reality or myth?. Molecular Oncology 2019. ISSN 1574-7891.s doi: 10.1002/1878-0261.12420.
  • Lellahi, Seyed Mohammad; Rosenlund, Ingrid Arctander; Hedberg, Annica; Kiær, Liv Torill; Mikkola, Ingvild; Knutsen, Erik; Perander, Maria. The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response. Journal of Biological Chemistry 2018; Volum 293 (49). ISSN 0021-9258.s 18965 - 18976.s doi: 10.1074/jbc.RA118.004473.
  • Shen, Peng; Reineke, Lucas C.; Knutsen, Erik; Chen, Meng; Pichler, Martin; Ling, Hui; Calin, George A.. Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling. Molecular Oncology 2018; Volum 12 (11). ISSN 1574-7891.s 1856 - 1870.s doi: 10.1002/1878-0261.12384.
  • Dragomir, Mihnea-Paul; Knutsen, Erik; Calin, George A.. SnapShot: Unconventional miRNA Functions. Cell 2018. ISSN 0092-8674.
  • Figenschau, Stine; Knutsen, Erik; Urbarova, Ilona; Fenton, Christopher Graham; Elston, Bryan; Perander, Maria; Mortensen, Elin Synnøve; Fenton, Kristin Andreassen. ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes. Scientific Reports 2018; Volum 8:11720. ISSN 2045-2322.s 1 - 12.s doi: 10.1038/s41598-018-29604-2.
  • Hedberg, Annica; Knutsen, Erik; Løvhaugen, Anne Silje; Jørgensen, Tor Erik; Perander, Maria; Johansen, Steinar Daae. Cancer-specific SNPs originate from low-level heteroplasmic variants in human mitochondrial genomes of a matched cell line pair. Mitochondrial DNA. Part A, DNA Mapping, Sequencing, and Analysis 2018; Volum 30 (1). ISSN 2470-1394.s 82 - 91.s doi: 10.1080/24701394.2018.1461852.
  • Haldorsson, Skarphedinn; Rohatgi, Neha; Magnusdottir, Manuela; Choudhary, Kumari; Gudjónsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdòttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild; Gudmundsson, Steinn; Rolfsson, Ottar. Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition. Cancer Letters 2017; Volum 396. ISSN 0304-3835.s 117 - 129.s doi: 10.1016/j.canlet.2017.03.019.
  • Fiskaa, Tonje; Knutsen, Erik; Nikolaisen, Malene; Jørgensen, Tor Erik; Johansen, Steinar Daae; Perander, maria; Seternes, Ole Morten. Distinct small RNA signatures in extracellular vesicles derived from breast cancer cell lines. PLOS ONE 2016; Volum 11 (8). ISSN 1932-6203.s doi: 10.1371/journal.pone.0161824.
  • Roth, Sarah A; Knutsen, Erik; Fiskaa, Tonje; Utnes, Peter Andree; Bhavsar, Swapnil Parashram; Hald, Øyvind; Løkke, Cecilie; Mestdagh, Pieter; Johansen, Steinar Daae; Flægstad, Trond; Einvik, Christer. Next generation sequencing of microRNAs from isogenic neuroblastoma cell lines isolated before and after treatment. Cancer Letters 2016; Volum 372 (1). ISSN 0304-3835.s 128 - 136.s doi: 10.1016/j.canlet.2015.11.026.
  • El-Gewely, M. Raafat; Andreassen, Morten; Walquist, Mari; Ursvik, Anita; Knutsen, Erik; Nystad, Mona; Coucheron, Dag H; Myrmel, Kristin Smistad; Hennig, Rune; Johansen, Steinar Daae. Differentially expressed micro RNAs in meningiomas grades I and II suggest shared biomarkers with malignant tumors. Cancers 2016; Volum 8:31 (3). ISSN 2072-6694.s doi: 10.3390/cancers8030031.
  • Knutsen, Erik; Perander, maria; Fiskaa, Tonje; Johansen, Steinar Daae. Performance Comparison and Data Analysis Strategies for MicroRNA Profiling in Cancer Research. Springer 2015 ISBN 978-3-319-15811-2.s doi: 10.1007/978-3-319-15811-2_15.
  • Knutsen, Erik; Fiskaa, Tonje; Ursvik, anita; Jørgensen, Tor Erik; Perander, maria; Lund, Eiliv; Seternes, Ole Morten; Johansen, Steinar; Andreassen, morten. Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines. PLOS ONE 2013; Volum 8 (10). ISSN 1932-6203.s doi: 10.1371/journal.pone.0075813.
  • Knutsen, Erik; Perander, Maria. Forhøyede nivåer av NEAT1 er assosiert med HER2 positiv brystkreft. 2020.
  • Knutsen, Erik; Perander, maria; Johansen, Steinar Daae; Andreassen, morten. Study of functional RNA using high-throughput profiling technologies in a human cell model system. Cell Symposia: Functional RNA’s 2012-12-02 - 2012-12-04 2012.
  • Knutsen, Erik; Andreassen, morten; Fiskaa, Tonje; Ursvik, anita; Lund, Eiliv; Seternes, Ole Morten; Johansen, Steinar Daae. MiRNA expression profiling based on different high-throughput platforms reveals surprising variations. ncRNAs and Human Disease International symposium 2011-08-25 - 2011-08-26 2011.
  • Johansen, Steinar Daae; Andreassen, morten; Babiak, Igor; Bizuayehu, Teshome; Coucheron, Dag-Hugo; El-Gewely, M. Raafat; Emblem, Åse; Fiskaa, Tonje; Furmanek, Tomasz; Haugli, kari b.; Karlsen, Bård Ove; Klingan, Kevin; Knutsen, Erik; Jørgensen, Tor Erik; Moum, Truls Borg; Nordeide, Jarle Tryti; Okkenhaug, Siri; Rekvig, Ole Petter; Seternes, ole morten; Ursvik, anita. Investigating miRNAs and transcriptomes at our local SOLiD sequencing facility. The Norwegian Biochemical Society 47th Contact Meeting 2011-02-03 - 2011-02-06 2011.
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    Research interests

    I’m currently leading a single cell RNA-sequencing project with the aim of subclassifying breast cancer cell present in the lymph nodes for better personalized diagnosis and treatment. The project will assess the transcriptional changes in breast cancer cells as they are subjected to the microenvironment of the lymph nodes, and will examine the impact of this new microenvironment on epithelial mesenchymal transition, cancer stem cells, and risk of metastasis, recurrence, and dormancy. The project combines the use of fresh patient samples, bioinformatics, and in vivo and in vitro models. I have an ambition to better diagnosis for breast cancer patients to prevent overtreatment with serious side effects, to generate new basic knowledge on metastasis, and to find new targets for prevention of metastasis. I further want to tackle the problem of tumor dormancy, as this is one of the great challenges when it comes to relapse and metastasis. I believe solving the problems of metastasis and tumor dormancy can only be reached by a strong collaboration between clinicians/ oncologists, bioinformaticians, and molecular biologists, and I have therefore established such collaborations locally, nationally, and internationally.


    Member of research group


    CV

    Research Experience

    08-2020-Present, UiT The Arctic University of Norway, Researcher (Principal Investigator)

    04-2017-07-2020, UiT The Arctic University of Norway, Postdoctoral fellow                     

    PI: Maria Perander

    02-2018-02-2019, University of Texas MD Anderson Cancer Center, Postdoctoral fellow                     

    PI: George A. Calin

    01-2017-04-2017, UiT The Arctic University of Norway, Associate professor

    05-2016-12-2016, UiT The Arctic University of Norway, Head engineer

    06-2011-12-2011, UiT The Arctic University of Norway, Scientific assistant

    06-2010-08-2010, GenØk, Laboratory assistant


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