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Bård Smedsrød


Professor emeritus / work package leader of the RCN project LUPCON

Job description

Professor emeritus / work package leader of the RCN project LUPCON


  • Julian Philipp, Aleksandra Dabkowska, Anita Reiser, Kilian Frank, Rafał Krzysztoń, Christiane Brummer et al.:
    pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function
    Proceedings of the National Academy of Sciences of the United States of America 2023 ARKIV / DOI
  • Milton Boaheng Antewi, Gianina Aurica Dumitriu, Jaione Santamaria Simon, Javier Sanchez Romano, Ruomei Li, Bård Smedsrød et al.:
    Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIb, yet maintain a preserved fenestration in the Glmp gt/gt mouse model of slowly progressing liver fibrosis
    PLOS ONE 2023 ARKIV / DOI
  • Ruomei Li, Sabin Bhandari, Inigo Zubiavrre Martinez, Jack-Ansgar Bruun, Ilona Halva Urbarova, Bård Smedsrød et al.:
    Changes in the proteome and secretome of rat liver sinusoidal endothelial cells during early primary culture and effects of dexamethasone
    PLOS ONE 2022 ARKIV / DOI
  • Kjetil Elvevold, Ingelin Kyrrestad, Bård Smedsrød :
    Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution
    Methods in molecular biology 2022 ARKIV / DOI
  • Anett Kristin Larsen, Jaione Simon-Santamaria, kjetil helge Elvevold, Bo Gøran Ericzon, Kim Erlend Mortensen, Peter Anthony McCourt et al.:
    Autofluorescence in freshly isolated adult human liver sinusoidal cells
    European journal of histochemistry 2021 ARKIV / DOI
  • Sabin Bhandari, Anett Kristin Larsen, Peter Anthony McCourt, Bård Smedsrød, Karen Kristine Sørensen :
    The scavenger function of liver sinusoidal endothelial cells in health and disease
    Frontiers in Physiology 11. October 2021 ARKIV / DOI
  • Karen Kristine Sørensen, Bård Smedsrød :
    The Liver Sinusoidal Endothelial Cell: Basic Biology and Pathobiology
    John Wiley & Sons 2020
  • Cristina Ionica Øie, Deanna Wolfson, Tanji Yasunori, Gianina Dumitriu, Karen Kristine Sørensen, Peter Anthony McCourt et al.:
    Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses.
    Scientific Reports 2020 ARKIV / DOI
  • Willeke De Haan, Cristina Ionica Øie, Mohammed Benkheil, Wouter Dheedene, Stefan Vinckier, Giulia Coppiello et al.:
    Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization
    American Journal of Physiology - Gastrointestinal and Liver Physiology 2020 DOI
  • Sabin Bhandari, Ruomei Li, Jaione Simon-Santamaria, Peter Anthony McCourt, Steinar Daae Johansen, Bård Smedsrød et al.:
    Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages
    BMC Molecular and Cell Biology 2020 ARKIV / DOI
  • Wiebke Albrecht, Franziska Kappenberg, Tim Brecklinghaus, Regina Stoeber, Rosemarie Marchan, Mian Zhang et al.:
    Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
    Archives of Toxicology 2019 ARKIV / DOI
  • Richard England, Jennifer Moss, Kathryn J Hill, kjetil helge Elvevold, Bård Smedsrød, Marianne B Ashford :
    Evaluating liver uptake and distribution of different poly(2-methyl-2-oxazoline) modified lysine dendrimers following intravenous administration
    Biomaterials Science 2019 DOI
  • Aitor Benedicto, Alba Herrero, Irene Romayor, Joana Marquez, Bård Smedsrød, Elvira Olaso et al.:
    Liver sinusoidal endothelial cell ICAM-1 mediated tumor/endothelial crosstalk drives the development of liver metastasis by initiating inflammatory and angiogenic responses
    Scientific Reports 2019 ARKIV / DOI
  • Kalle Sigfridsson, Pia Skantze, Urban Skantze, Lena Svensson, Lars Lofgren, Pär Nordell et al.:
    Nanocrystal formulations of a poorly soluble drug. 2. Evaluation of nanocrystal liver uptake and distribution after intravenous administration to mice
    International Journal of Pharmaceutics 2017 DOI
  • Leif Longva, Eirik Reierth, Lars Moksness, Bård Smedsrød :
    Peer reviewing: a private affair between the individual researcher and the publishing houses, or a responsibility of the university?
    Journal of Electronic Publishing 22. May 2017 ARKIV / DOI
  • Caroline Godfrey, Lourdes R. Desviat, Bård Smedsrød, France Piétri-Rouxel, Michela A. Denti, Petra Disterer et al.:
    Delivery is key: lessons learnt from developing splice-switching antisense therapies
    EMBO Molecular Medicine 2017 ARKIV / DOI
  • Kalle Sigfridsson, Urban Skantze, Pia Skantze, Svante Johansson, Iain Grant, Bård Smedsrød et al.:
    Nanocrystal formulations of a poorly soluble drug. 1. In vitro characterization of stability, stabilizer adsorption and uptake in liver cells
    International Journal of Pharmaceutics 2017 DOI
  • Cristina Ionica Øie, Kirstine Roepstorff, Carsten Behrens, Jesper Bøggild Kristensen, Ditte Maria Karpf, Gert Bolt et al.:
    High-affinity von Willebrand factor binding does not affect the anatomical or hepatocellular distribution of factor VIII in rats
    Journal of Thrombosis and Haemostasis 2016 ARKIV / DOI
  • Geir Ivar Nedredal, Kjetil Helge Elvevold, MF Chedid, Lars Marius Ytrebø, CF Rose, S Sen et al.:
    Pulmonary vascular clearance of harmful endogenous macromolecules in a porcine model of acute liver failure
    Annals of Hepatology 2016 SAMMENDRAG / ARKIV / DOI
  • Cristina Ionica Øie, Igor Snapkov, Kjetil Elvevold, Baldur Sveinbjørnsson, Bård Smedsrød :
    FITC conjugation markedly enhances hepatic clearance of N-formyl peptides
    PLOS ONE 2016 ARKIV / DOI
  • Karen Kristine Sørensen, Jaione Simon-Santamaria, Robert S. McCuskey, Bård Smedsrød :
    Liver sinusoidal endothelial cells
    Comprehensive Physiology 2015 DOI
  • Adil El Taghdouini, Anita Løvstad Sørensen, Andrew Henry Reiner, Mar Coll, Stefaan Verhulst, Inge Mannaerts et al.:
    Genome-wide analysis of DNA methylation and gene Expression patterns in purified, uncultures human liver cells and activated hepatic stellate cells
    OncoTarget 2015 ARKIV / DOI
  • Jaione Simon-Santamaria, Christine Hanssen Rinaldo, Piotr Kardas, Ruomei Li, Ivana Malovic, kjetil helge Elvevold et al.:
    Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta
    PLOS ONE 2014 ARKIV / DOI
  • Viola Mönkemöller, Mark Schuttpelz, Peter Anthony McCourt, Karen Kristine Sørensen, Bård Smedsrød, Thomas Rolf Huser :
    Imaging fenestrations in liver sinusoidal endothelial cells by optical localization microscopy
    Physical Chemistry, Chemical Physics - PCCP 07. May 2014 DOI
  • A. El Taghdouini, A. L. Sørensen, M. Coll, I. Mannaerts, Cristina Ionica Øie, Å. A. Fretland et al.:
    P605 gene expression and dna methylation profiling of distinct adult human liver cells and culture-activated hepatic stellate cells
    Journal of Hepatology 2014 DOI
  • Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Kim Erlend Mortensen, Ingelin Kyrrestad Karlstrøm, Eirik Abrahamsen Lænsman et al.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream.
    Journal of Hepatology 2023 DOI
  • Javier Sanchez Romano, Jaione Santamaria Simon, Peter Anthony Gerard Mccourt, Christopher Florian Holte, Bård Smedsrød, Antonia Sagona et al.:
    Rapid blood clearance of phage K1F-GFP is mediated by the liver and executed by Kupffer cells and liver sinusoidal endothelial cells in collaboration
    2023
  • Anett Kristin Larsen, Javier Sanchez Romano, Eirik Abrahamsen Lænsman, Anne Lotte Vada Hatlegjerde, Jaione Simon-Santamaria, Kim Erlend Mortensen et al.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream
    2022
  • Javier Sanchez Romano, Anett Kristin Larsen, Jaione Simon-Santamaria, Cristina Ionica Øie, Bård Smedsrød, Peter Anthony McCourt et al.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Javier Sanchez Romano, Anett Kristin Larsen, Jaione Simon-Santamaria, Cristina Ionica Øie, Bård Smedsrød, Peter Anthony McCourt et al.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Anett Kristin Larsen, Javier Sanchez Romano, Jaione Simon-Santamaria, Kim Erlend Mortensen, Bo Gøran Ericzon, Peter Anthony McCourt et al.:
    Role of liver sinusoidal endothelial cells in elimination of virus
    2022
  • Leif Longva, Bård Smedsrød :
    Stans gratisarbeidet for grådige tidsskriftsforlag
    Khrono.no 26. December 2021 ARKIV
  • Bård Smedsrød :
    Old drugs to reinvigorate old liver cells
    The journals of gerontology. Series A, Biological sciences and medical sciences 2020 DOI
  • Anett Kristin Larsen, Jaione Simon-Santamaria, kjetil helge Elvevold, Bo G. Ericzon, Bård Smedsrød, Karen Kristine Sørensen :
    Autofluorescence in freshly isolated adult human liver sinusoidal cells
    2019
  • Sabin Bhandari, Ruomei Li, Ingelin Kyrrestad, Jack-Ansgar Bruun, Ilona Urbarova, Bård Smedsrød et al.:
    Effect of glucocorticoids on liver sinusoidal endothelial cells in vitro
    2019
  • Javier Sanchez Romano, Anett Kristin Larsen, kjetil helge Elvevold, Christopher Florian Holte, Jaione Simon-Santamaria, Hans H. Hirsch et al.:
    SECVIR - The role of scavenger endothelial cells in elimination of virus
    2019
  • Ingelin Kyrrestad, Ruomei Li, Sabin Bhandari, Jaione Simon-Santamaria, Bård Smedsrød, Karen Kristine Sørensen :
    A protocol for in vitro toxicity studies in liver sinusoidal endothelial cells
    2019
  • Karen Kristine Sørensen, Milton Boaheng Antwi, Gianina Dumitriu, Ruomei Li, Bård Smedsrød, Winnie Eskild :
    Scavenger function of liver sinusoidal endothelial cells in a transgenic mouse model of liver fibrosis is reduced
    2019
  • Leif Longva, Jan Erik Frantsvåg, Bård Smedsrød :
    Plan S og implementering
    Khrono.no 05. November 2018 ARKIV / FULLTEKST
  • Bård Smedsrød :
    Episode #9 I serien Nå Er Det Alvor: Bård Smedsrød - en mann som lever for å levere
    02. March 2018 DATA
  • Bård Smedsrød :
    Carnivore-dietten, fasting, sukker, helsetrender, vitaminer, mineraler + +
    21. July 2018 DATA
  • Bård Smedsrød :
    The problem with peer review
    23. October 2018 DATA
  • Bård Smedsrød, Leif Longva, Jan Erik Frantsvåg :
    Voldsom sløsing med offentlige penger i vitenskapelig publisering
    Dagens næringsliv 28. February 2018 ARKIV
  • Deanna Wolfson, Cristina Ionica Øie, Tanji Yasunori, Gianina Dumitriu, Peter Anthony McCourt, Karen Kristine Sørensen et al.:
    Uptake and Degradation of Bacteriophages by Liver Sinusoidal Endothelial Cells
    2018 ARKIV
  • Deanna Wolfson, Cristina Ionica Øie, Yasunori Tanji, Karen Kristine Sørensen, Peter Anthony McCourt, Bård Smedsrød et al.:
    Multimodal Microscopy to Study the Fate of Bacteriophages in Liver Sinusoidal Endothelial Cells
    2017
  • Sabin Bhandari, Ruomei Li, Jaione Simon-Santamaria, Peter Anthony McCourt, Steinar Daae Johansen, Bård Smedsrød et al.:
    The liver sinusoidal endothelial cell – an endothelial cell with a macrophage-like identity
    2017
  • Ruomei Li, Jaione Simon-Santamaria, Sabin Bhandari, Jack-Ansgar Bruun, Ilona Urbarova, Bård Smedsrød et al.:
    Phenotypic changes in rat liver sinusoidal endothelial cells during early stages of in vitro culture
    2017
  • Jaione Simon-Santamaria, Ruomei Li, Sabin Bhandari, Jack-Ansgar Bruun, Bård Smedsrød, Inigo Zubiavrre Martinez et al.:
    Secretome of the liver sinusoidal endothelial cell
    2016
  • Sabin Bhandari, Ruomei Li, Jaione Simon-Santamaria, Peter Anthony McCourt, Steinar Daae Johansen, Bård Smedsrød et al.:
    Next generation deep sequencing of rat liver sinusoidal endothelial cell and Kupffer cell transcriptomes suggests functional complementarity
    2016
  • Jaione Simon-Santamaria, Christine H Rinaldo, Piotr Kardas, Ruomei Li, Ivana Malovic, Kjetil H. Elvevold et al.:
    Role of scavenger endothelial cells in polyomavirus JC and BK clearance
    2014

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    Research interests

    Role of the scavenger endothelial cell of the vertebrate kingdom, in particular the mammalian liver sinusoidal endothelial cell, in the clearance of colloids and nano particles from the blood circulation.


    Member of research group


    Member of project


    CV

    Qualifications:
    1975: Norwegian Cand. Mag. degree (similar to Bachelor degree), at the University of Oslo
    1978: Norwegian Cand. Real. exam (similar to Master degree), at the University of Tromsø
    1984: Ph.D., Uppsala University, Sweden

    Previous employment:

    1978-1979: Research assistant, Institute of Medical Biology, University of Tromsø.
    1979-1981: Research scientist in prof. David Aminoff´s group, Department of Biochemistry,        University of Michigan, Ann Arbor, USA
    1981-1984: Predoctoral research position at University of Uppsala, Sweden, employed by the Veterinary School, the Swedish Agricultural Universtity (supervisors: profs. Ulf Lindahl and Torvard C. Laurent), ending December 1984 by defending Ph.D. thesis "Endocytosis of connective tissue macromolecules in liver endothelial cells". The thesis was later (1988) awarded as the best thesis defended at the Swedish Agricultural University during the period 1984 - 1987.
    1983-1988: Part time (20%) position as research consultant (eukaryot cell biology), at KabiGen, a subsidiary under KabiVitrum (presently Pharmacia-Upjohn), Stockholm, Sweden.
    1985-1988: Associate professor at Dep. Med. and Physiol. Chemistry, Medical Faculty, University of Uppsala.
    1988-1990: Senior scientist at Dep. Biochem., University of Tromsø, Norway, paid by a grant from the Norwegian Cancer Association.
    1990-1992: Associate professor at Dep. of Exper. Pathol., University of Tromsø, Norway.
    1993-Present Full professor at Vascular Biology Research Group, Department of Medical Biology, University of Tromsø.

    Visiting professor:

    1994-1995: Visiting professor at the Department of Medical Chemistry and Physiology, Biomedical Centre, University of Uppsala. Host: Prof. Kristofer Rubin.
    1999-2000: Visiting professor at Dep. Biochem. Mol. Biol., Univ.Oklahoma Health Sci. Center, Oklahoma City.