Bilde av Sylte, Ingebrigt
Bilde av Sylte, Ingebrigt
Eksperimentell og klinisk farmakologi ingebrigt.sylte@uit.no +4777644705 You can find me here

Ingebrigt Sylte


Professor, research group leader


  • Ingebrigt Sylte, Mari Gabrielsen, kurt Kristiansen :
    Homology Modeling of Transporter Proteins
    Methods in molecular biology 2023 ARKIV / DOI
  • Kyohei Imai, Rysouke Saito, Takyua Ezawa, Satoshi Sugiyama, Ingebrigt Sylte, Noriyuki Kurita :
    Proposal of selective inhibitor for bacterial zinc metalloprotease: Molecular mechanics and ab initio molecular orbital calculations
    Journal of Molecular Graphics and Modelling 2022 ARKIV / DOI
  • Fatema Rahman, Tra-Mi Nguyen, Olayiwola Adekoya, Cristina Campestre, Paolo Tortorella, Ingebrigt Sylte et al.:
    Inhibition of bacterial and human zincmetalloproteases by bisphosphonate- and catechol-containing compounds
    Journal of Enzyme Inhibition and Medicinal Chemistry 2021 ARKIV / DOI
  • Fatema Rahman, Imin Wushur, Nabin Malla, Ove Alexander Høgmoen Åstrand, Pål Rongved, Jan-Olof Winberg et al.:
    Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases
    Molecules 2021 ARKIV / DOI
  • Ryosuke Saito, Kyohei Imai, Shohei Yamamoto, Takuya Ezawa, Satohsi Sugiyama, Linn Evenseth et al.:
    Specific interactions between the alkaline protease of P. aeruginosa and its natural peptide inhibitor: ab initio molecular simulations
    Journal of Molecular Modeling 2021 ARKIV / DOI
  • Takuya Ezawa, Ryosuke Saito, Shusuke Suzuki, Satoshi Sugiyama, Ingebrigt Sylte, Noriyuki Kurita :
    Protonation states of central amino acids in a zinc metalloprotease complexed with inhibitor: Molecular mechanics optimizations and ab initio molecular orbital calculations
    Biophysical Chemistry 2020 ARKIV / DOI
  • Rangita Dawadi, Nabin Malla, Beate Hegge, Imin Wushur, Eli Berg, Gunbjørg Svineng et al.:
    Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer
    International Journal of Molecular Sciences 2020 ARKIV / DOI
  • Linn Evenseth, Riccardo Ocello, Mari Gabrielsen, Matteo Masetti, Maurizio Recanatini, Ingebrigt Sylte et al.:
    Exploring Conformational Dynamics of the Extracellular Venus flytrap Domain of the GABA B Receptor: A Path-Metadynamics Study
    Journal of Chemical Information and Modeling 2020 ARKIV / DOI
  • Linn Evenseth, Mari Gabrielsen, Ingebrigt Sylte :
    The GABAB Receptor—Structure, Ligand Binding and Drug Development
    Molecules 2020 ARKIV / DOI
  • Åse-Karen Mortensen, Silje Mæhre, kurt Kristiansen, Eldbjørg Sofie Heimstad, Geir W. Gabrielsen, Bjørn Munro Jenssen et al.:
    Homology modeling to screen for potential binding of contaminants to thyroid hormone receptor and transthyretin in glaucous gull (Larus hyperboreus) and herring gull (Larus argentatus)
    Computational Toxicology 2020 ARKIV / DOI
  • Linn Evenseth, Dawid Warszycki, Andrzej J Bojarski, Mari Gabrielsen, Ingebrigt Sylte :
    In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds
    Molecules 2019 ARKIV / DOI
  • Marthe Fredheim Fjelldal, Thibaud Freyd, Linn Evenseth, Ingebrigt Sylte, Avi Ring, Ragnhild Elisabeth Paulsen :
    Exploring the overlapping binding sites of ifenprodil and EVT‐101 in GluN2B‐containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling
    Pharmacology Research & Perspectives 2019 ARKIV / DOI
  • Takuya Ezawa, Satoshi Sugiyama, Ayami Ara, Ingebrigt Sylte, Noriyuki Kurita :
    Design of galardine analogs as putative psudolysin inhibitors based on ab initio fragment molecular orbital calculations
    Journal of Biomolecular Structure and Dynamics 2019 ARKIV / DOI
  • Liv Henriette Arnesen, Nadia Haj Yasein, Jørn Eivind Tungen, Helen Södling, Jason Matthews, Steinar M Paulsen et al.:
    Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist
    Bioorganic & Medicinal Chemistry 15. September 2019 FULLTEKST / ARKIV / DOI
  • Linn M Evenseth, Kurt Kristiansen, You Song, Knut Erik Tollefsen, Ingebrigt Sylte :
    In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding
    Computational Toxicology 2019 ARKIV / DOI
  • Katie L. Hill, Åse-Karen Mortensen, Daniel Teclechiel, William G. Willmore, Ingebrigt Sylte, Bjørn Munro Jenssen et al.:
    In Vitro and in Silico Competitive Binding of Brominated Polyphenyl Ether Contaminants with Human and Gull Thyroid Hormone Transport Proteins
    Environmental Science and Technology 2018 ARKIV / DOI
  • Ingebrigt Sylte, Rangita Dawadi, Nabin Malla, Susannah von Hofsten, Tra-Mi Nguyen, Ann Iren Solli et al.:
    The selectivity of galardin and an azasugar-based hydroxamate compound for human Matrix metalloproteases and bacterial metalloproteases
    PLOS ONE 2018 ARKIV / DOI
  • Jon A. Doering, Sehan Lee, kurt Kristiansen, Linn Evenseth, Ingebrigt Sylte, Mace G. Barron et al.:
    In silico site-directed mutagenesis informs species-specific predictions of chemical susceptibility derived from the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool
    Toxicological Sciences 2018 DOI
  • Nora Al-Kazaale, Phuong Dan Dinh Tran, Farhad Haidari, Eirik Johansson Solum, Sandra Liekens, Peter Vervaeke et al.:
    Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol
    Steroids 2018 DOI
  • Thibaud Freyd, Dawid Warszycki, Stefan Mordalski, Andrzej J Bojarski, Ingebrigt Sylte, Mari Gabrielsen :
    Ligand-guided homology modelling of the GABA<sub>B2</sub> subunit of the GABA<sub>B</sub> receptor
    PLOS ONE 2017 ARKIV / DOI
  • Ayami Ara, Ryushi Kadoya, Hiromi Ishimura, Kanako Shimamura, Ingebrigt Sylte, Noriyuki Kurita :
    Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations
    Journal of Molecular Graphics and Modelling 2017 DOI
  • Dawid Warszycki, Manuel Rueda, Stefan Mordalski, kurt Kristiansen, Grzegorz Satala, Krzysztof Rataj et al.:
    From Homology Models to a Set of Predictive Binding Pockets-a 5-HT<sub>1A</sub> Receptor Case Study
    Journal of Chemical Information and Computer Sciences 2017 DOI
  • Elvar Örn Viktorsson, Mari Gabrielsen, Nugalya Kumarachandran, Ingebrigt Sylte, Pål Rongved, Ove Alexander Høgmoen Åstrand et al.:
    Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations
    Steroids 2017 DOI
  • Zdzislaw Chilmonczyk, Andrzej J. Bojarski, Andrzej Pilc, Ingebrigt Sylte :
    Serotonin transporter and receptor ligands with antidepressant activity as neuroprotective and proapoptotic agents
    Pharmacological Reports 2017 DOI
  • Ove Alexander Høgmoen Åstrand, Elvar Örn Viktorsson, Aleksander Lim Kristensen, Dag Ekeberg, Hanne Røberg-Larsen, Steven Ray Haakon Wilson et al.:
    Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors
    Journal of Steroid Biochemistry and Molecular Biology 2017 ARKIV / DOI
  • Stian Sjøli, Elisa Nuti, Caterina Camodeca, Irina Bilto, Armando Rossello, Jan-Olof Winberg et al.:
    Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors
    European Journal of Medicinal Chemistry 2016 ARKIV / DOI
  • Heli Anna Irmeli Routti, Roger Lille-Langøy, Mari Katrine Berg, Trine Fink, Mikael Harju, Kurt Kristiansen et al.:
    Environmental chemicals modulate polar bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and adipogenesis in vitro
    Environmental Science and Technology 2016 DOI
  • Odutayo O. Odunuga, Olayiwola Adekoya, Ingebrigt Sylte :
    High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification
    Protein Expression and Purification 2015 DOI
  • Eirik Johansson Solum, Jing-Jy Cheng, Ingebrigt Sylte, Anders Vik, Trond Vidar Hansen :
    Synthesis, biological evaluation and molecular modeling of new analogs of the anti-cancer agent 2-methoxyestradiol: potent inhibitors of angiogenesis
    RSC Advances 2015 ARKIV / DOI
  • Åsmund Kaupang, Steinar Martin Paulsen, Calin Constantin Steindal, Aina Westrheim Ravna, Ingebrigt Sylte, Trine Grønhaug Halvorsen et al.:
    Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618
    European Journal of Medicinal Chemistry 2015 ARKIV / DOI
  • Zdzislaw Chilmonczyk, Andrzej Jacek Bojarski, Andrzej Pilc, Ingebrigt Sylte :
    Functional selectivity and antidepressant activity of serotonin 1A receptor ligands
    International Journal of Molecular Sciences 2015 ARKIV / DOI
  • Imin Wushur, Ingebrigt Sylte, Jan-Olof Winberg :
    The catalytic reaction mechanism of drosophilid alcohol dehydrogenases
    Perspectives in Science 2015 ARKIV / DOI
  • Ove Alexander Høgmoen Åstrand, Marcel Sandberg, Ingebrigt Sylte, Carl Henrik Gorbitz, G. Hege Thoresen, Eili Tranheim Kase et al.:
    Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol
    Bioorganic & Medicinal Chemistry 2014 DOI
  • Ibrahim Jantan, Syed Nasir Abbas Bukhari, Olayiwola Adekoya, Ingebrigt Sylte :
    Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A<sub>2</sub>, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines
    Drug Design, Development and Therapy 2014 ARKIV / DOI
  • Imin Wushur, Jan-Olof Winberg, Ingebrigt Sylte :
    Comparative molecular dynamic simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase
    Journal of Biomolecular Structure and Dynamics 2014 DOI
  • Olayiwola Adekoya, Stian Sjøli, Imin Wushur, Irina Bilto, Sergio M Marques, M Amelia Santos et al.:
    Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors
    European Journal of Medicinal Chemistry 2014 DOI
  • Zdzislaw Chilmonczyk, Andrzej J. Bojarski, Ingebrigt Sylte :
    Ligand-directed traffickingof receptor stimulus
    Pharmacological Reports 2014 DOI
  • Fatema Rahman, Imin Wushur, Ingebrigt Sylte, Jan-Olof Winberg :
    Extracellular human and bacterial zinc metalloproteases – challenges in design of specific inhibitors
    NBS-nytt 2021
  • Knut-Erik Tollefsen, Marc Timothy David Cronin, Linn Evenseth, James W. Firman, Taisen Iguchi, Carlie Lalone et al.:
    Endocrine Disruption in crustaceans – a “new” environmental challenge?
    2019
  • Knut Erik Tollefsen, Marc Timothy David Cronin, Øystein Evensen, Linn Evenseth, Francesco Falciani, Taisen Iguchi et al.:
    AOP-informed assessment of Endocrine Disruption in freshwater crustaceans
    2018
  • Knut Erik Tollefsen, Marc Timothy David Cronin, Linn Evenseth, James W. Firman, Taisen Iguchi, Carlie Lalone et al.:
    AOP-informed chemical screening, prioritization and risk assessment of arthropod Endocrine Disruptors
    2018
  • You Song, Daniel L. Villeneuve, Taisen Iguchi, Thomas Rundberget, Claire Mellor, Marc Timothy David Cronin et al.:
    Development of invertebrate Adverse Outcome Pathways (AOPs) for mechanistically-based risk assessment
    2017
  • You Song, Daniel L. Villeneuve, Taisen Iguchi, Thomas Rundberget, Claire Mellor, Marc Timothy David Cronin et al.:
    Development of invertebrate Adverse Outcome Pathways (AOPs) for mechanistically-based risk assessment
    2017
  • You Song, Daniel L. Villeneuve, Taisen Iguchi, Neus Rodriguez-Sanchez, Thomas Rundberget, Claire Mellor et al.:
    Development of invertebrate Adverse Outcome Pathways (AOPs) for mechanistically-based risk assessment
    2017
  • Thomas Sæther, Angel Moldes-Anaya, Jørn Eivind Tungen, Anders Vik, Steinar M Paulsen, Ingebrigt Sylte et al.:
    Anti-diabetic activity from marine lipids: new anti-diabetic drugs
    2016
  • Åse-Karen Mortensen, Bjørn Munro Jenssen, Geir W. Gabrielsen, Ingebrigt Sylte, Eldbjørg Sofie Heimstad :
    Competitive binding of persistent organic pollutants to the thyroid hormone transport protein transthyretin in Glaucous gull (Larus hypoerboreus)
    2015
  • Thomas Sæther, Angel Moldes-Anaya, Jørn Eivind Tungen, Anders Vik, Steinar Martin Paulsen, Ingebrigt Sylte et al.:
    Anti-diabetic activity from marine lipids: new anti-diabetic drugs
    2015
  • You Song, Mark T. Cronin, Øystein Evensen, Francesco Falciani, Tore Høgåsen, Taisen Iguchi et al.:
    Development of adverse outcome pathways for endocrine disruption in Daphnia magna
    2014
  • You Song, Philipp Antczak, Mark T. Cronin, Linn Evenseth, Øystein Evensen, Francesco Falciani et al.:
    Development of adverse outcome pathways for endocrine disruption in Daphnia magna
    2014
  • You Song, Mark T. Cronin, Øystein Evensen, Francesco Falciani, Natalia Garcia-Reyero, Tore Høgåsen et al.:
    EDRISK: Development of adverse outcome pathways for endocrine disruption in Daphnia magna
    2014

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    Research interests

    • Receptors and transporters in the CNS as drug targets
    • Molecular mechanisms and inhibition of bacterial and human zinc proteases

    Teaching

    Pharmacology and molecular modelling