Hege Lynum Pedersen

Associate professor and research group leader of the RNA and Molecular Pathology research group

Job description

I work as an Assoociate Professor. My research interests are in immunology and protein research. I work with the autoimmune disease Systemic Lupus Erythematosus (SLE), and my focus has been mainly related to new biomarkers and treatment of this disease. 

  • Kristin Andreassen Fenton, Hege Lynum Pedersen :
    Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus
    Frontiers in medicine 2023 ARKIV / DOI
  • Luz P blanco, Eduardo Patino-Martinez, Shuichiro Nakabo, Mingzeng Zhang, Hege Lynum Pedersen, Xinghao Wang et al.:
    Modulation of the itaconate pathway attenuates murine lupus
    Arthritis & Rheumatology 2022 DOI
  • Kristel Berg, Hege Lynum Pedersen, Ingar Leiros :
    Biochemical characterization of ferric uptake regulator (Fur) from Aliivibrio salmonicida. Mapping the DNA sequence specificity through binding studies and structural modelling
    Biometals 2020 ARKIV / DOI
  • S Gupta, S Nakabo, Luz P. Blanco, LJ O'Neil, G Wigerblad, RR Goel et al.:
    Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism
    Proceedings of the National Academy of Sciences of the United States of America 2020 DOI
  • KA Fortner, Luz P. Blanco, I Buskiewicz, N Huang, PC Gibson, DL Cook et al.:
    Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice.
    Lupus Science and Medicine 2020 ARKIV / DOI
  • X Wang, Luz P. Blanco, Carmelo Carmona-Rivera, S Nakabo, Hege Lynum Pedersen, ZX Yu et al.:
    Gasdermin D modulates murine lupus and its associated organ damage
    Arthritis & Rheumatology 2020 DOI
  • Seyed Esmaeil Dorraji, Premasany Kanapathippillai, Aud-Malin Karlsson Hovd, Mikael Ryan Stenersrød, Kjersti Daae Horvei, anita Ursvik et al.:
    Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature
    American Journal of Pathology 2020 ARKIV / DOI
  • Luz P. Blanco, Hege Lynum Pedersen, Xinghao Wang, Yaima L. Lightfoot, Nickie Seto, Carmelo Carmona-Rivera et al.:
    Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone
    Arthritis & Rheumatology 2020 DOI
  • Dhivya Thiyagarajan, Hege Lynum Pedersen, Natalya Seredkina, Kjersti Daae Horvei, Lorena Arranz, Ramon Sonneveld et al.:
    IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene
    Frontiers in Cell and Developmental Biology 2018 ARKIV / DOI
  • Hege Lynum Pedersen, Kjersti Daae Horvei, Dhivya Thiyagarajan, Gudrun Norby, Natalya Seredkina, Gabriella Moroni et al.:
    Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression
    The journal of pathology. Clinical research 2018 ARKIV / DOI
  • Kjersti Daae Horvei, Hege Lynum Pedersen, Silje Fismen, Dhivya Thiyagarajan, Andrea Schneider, Ole Petter Rekvig et al.:
    Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease.
  • Ole Petter Rekvig, Dhivya Thiyagarajan, Hege Lynum Pedersen, Kjersti Daae Horvei, Natalya Seredkina :
    Future perspectives on pathogenesis of Lupus Nephritis: facts, problems, and potential causal therapy modalities
    American Journal of Pathology 2016 DOI
  • Hege Lynum Pedersen, Kenneth Johnson, Colin McVey, Ingar Leiros, Elin Moe :
    Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA
    Acta Crystallographica Section D: Biological Crystallography 2015 ARKIV / DOI
  • Hege Lynum Pedersen, Kjersti Daae Horvei, Dhivya Thiyagarajan, Natalya Seredkina, Ole Petter Rekvig :
    Murine and human lupus nephritis: pathogenic mechanisms and theoretical strategies for therapy
    Seminars in Nephrology 2015 DOI
  • Adele Kim Williamson, Hege Lynum Pedersen :
    Recombinant expression and purification of an ATP-dependent DNA ligase from Aliivibrio salmonicida
    Protein Expression and Purification 2014 DOI
  • Rafi Ahmad, Geir Åsmund Hansen, Hilde Hansen, Erik Hjerde, hege lynum Pedersen, steinar Paulsen et al.:
    Prediction, microarray and northern blot analyses identify new intergenic small RNAs in aliivibrio salmonicida
    Journal of Molecular Microbiology and Biotechnology 28. December 2012 DOI
  • hege lynum Pedersen, Rafi Ahmad, EK Riise, Hanna-Kirsti S. Leiros, Stefan Hauglid, S Espelid et al.:
    Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida)
    Journal of Microbiology 2010 DOI
  • hege lynum Pedersen, erik Hjerde, steinar Paulsen, Hilde Hansen, Lotte Olsen, Sunniva Katharina Thode et al.:
    Global responses of Aliivibrio salmonicida to hydrogen peroxide as revealed by microarray analysis
    Marine Genomics 2010 DOI
  • hege lynum Pedersen, Nils Peder Willassen, Ingar Leiros :
    The first structure of a cold-adapted superoxide dismutase (SOD): biochemical and structural characterization of iron SOD from Aliivibrio salmonicida
    Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2009 DOI
  • Kristin Andreassen Fenton, Hege Lynum Pedersen :
    Characterising tertiary lymphoid structures in lupus-prone mice
    Research Features Magazine 05. May 2021 DOI
  • Hege Lynum Pedersen, Luz P. Blanco, Xinghao Wang, Vance Holt, Mariana J. Kaplan :
    White blood cell metabolism in human SLE
  • Luz P. Blanco, Hege Lynum Pedersen, Yaima L. Lightfoot, Nickie Seto, Carmelo Carmona-Rivera, Yudong Liu et al.:
    The coenzyme Q10 analog idebenone ameliorates murine lupus
  • Hege Lynum Pedersen, Kjersti Daae Horvei, Dhivya Thiyagarajan, Gudrun Norby, Natalya Seredkina, Gabriella Moroni et al.:
  • Hege Lynum Pedersen :
    Lupus nefritt i mus og mennesker - hva har vi lært, og er det muligheter for terapi?
    Revmatologi BestPractice 2016
  • Hege Lynum Pedersen :
    MARZymes - Marine enzymes from the Arctic region
  • Adele Kim Williamson, Bjørn Altermark, hege lynum Pedersen, Gro Elin Kjæreng Bjerga, Marcin Miroslaw Pierechod, Nils Peder Willassen et al.:
    Discovery of Cold-active Enzymes from the Marine Arctic Environment
  • Adele Kim Williamson, Bjørn Altermark, Marcin Miroslaw Pierechod, Gro Elin Kjæreng Bjerga, hege lynum Pedersen, Concetta De Santi et al.:
    Hot Investigations into Cold-Sourced Enzymes
  • hege lynum Pedersen, Bjørn Altermark, Erik Hjerde, Adele Kim Williamson, Marcin Miroslaw Pierechod, Gro Elin Kjæreng Bjerga et al.:
    Genome Sequencing of Bacteria Isolated from the Arctic Marine Environment
  • Hege Lynum Pedersen, Laila Niiranen, Kjersti Lian, Aili Sarre, Joanna Timmins, Sean McSweeney et al.:
    Protein interaction studies of BER proteins from the extreme radiation resistant bacterium Deinococcus radiodurans
  • Hege Lynum Pedersen :
    Stress responses in Aliivibrio salmonicida
  • Laila Niiranen, Hege Lynum Pedersen, Kjersti Lien, Aili Sarre, Joanna Timmins, S McSweeney et al.:
    Identification of novel interaction partners for DNA glycosylases in the extreme radiation resistant bacterium Deinococcus radiodurans
  • Hege Lynum Pedersen :
    Oxidative stress and iron limitation in Aliivibrio salmonicida Expression profiling, and molecular characterisation of FeSOD and Fur
    UiT Norges arktiske universitet 2009
  • Hege Lynum Pedersen, Ellen Kristin Riise, Arne O. Smalås, Nils Peder Willassen :
    Oxidative stress in Vibrio salmonicida
  • Inger Liv Uttakleiv Ræder, hege lynum Pedersen, steinar Paulsen, Trond Jørgensen, Nils Peder Willassen, Arne Oskar Smalås :
    Proteomic studies of Vibrio Salmonicida

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    MBI-1105, basic biochemistry

    • Teaching in enzymology

    Responsible for the course ODO-2008

    • Teaching in immunology