Bilde av Hadler-Olsen, Elin Synnøve
Bilde av Hadler-Olsen, Elin Synnøve
Professor Department of Medical Biology elin.hadler-olsen@uit.no +4777620912 48197033

Elin Synnøve Hadler-Olsen


Job description

Professor oral anatomy and oral pathology

I am a dentist and teach about the structure and function of oral tissues in health and disease. My research is also focused on the mouth with various projects related to oral cancer and data on oral health and disease from epidemiological studies.


  • Kjersti Sellæg, Ruth Schwienbacher, Mathias Kranz, Anna Engan Aamodt, Anna Maria Wirsing, gerd Berge et al.:
    4-nitroquinoline 1-oxide-induced oral epithelial lesions exhibit time- and stage-dependent changes in the tumor immune microenvironment
    Frontiers in Oncology 2024 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Natalia Petrenya, Birgitta Jönsson, Ólöf Anna Steingrímsdóttir, Audun Stubhaug, Christopher Sivert Nielsen :
    Periodontitis is associated with decreased experimental pressure pain tolerance: The Tromsø Study 2015–2016
    Journal of Clinical Periodontology 2024 ARKIV / DOI
  • Malin Hansen, Michelle Palo, Marta Warzoszczak, Elin Synnøve Hadler-Olsen :
    Alkohol som risikofaktor for hode-halskreft – en litteraturstudie
    Den norske tannlegeforenings tidende 2023 FULLTEKST
  • Hege Nermo, Elin Synnøve Hadler-Olsen :
    Are dental visiting patterns and oral pain associated with dental disease among Norwegian adults? A cross-sectional study based on the Tromsø study
    Clinical and Experimental Dental Research 2023 ARKIV / DOI
  • Farah Asa'ad, Natalia Petrenya, Birgitta Jönsson, Gro Eirin Holde, Nils Oscarson, Elin Synnøve Hadler-Olsen et al.:
    Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity C-reactive protein and glycated hemoglobin: The Tromsø Study 2015-2016
    Journal of Periodontology 2023 ARKIV / DOI
  • Renate Harriet Andreassen, Birgitta Jönsson, Elin Synnøve Hadler-Olsen :
    Oral health related quality of life in long-term survivors of head and neck cancer compared to a general population from the seventh Tromsø study
    BMC Oral Health 2022 ARKIV / DOI
  • Juliane Winkler, Pengyuan Liu, Kiet Phong, Johanna H. Hinrichs, Nassim Ataii, Katherine Williams et al.:
    Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome
    Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2022 ARKIV / DOI
  • Sigurd Hadler-Olsen, Jeanett Steinnes, Hege Nermo, Anders Sjögren, Elin Synnøve Hadler-Olsen :
    Pain, discomfort, and functional impairment after extraction of primary teeth in children with palatally displaced canines–a randomized control trial comparing extraction of the primary canine versus extraction of the primary canine and the primary first molar
    Acta Odontologica Scandinavica 2022 ARKIV / DOI
  • Renate Andreassen, Elin Synnøve Hadler-Olsen :
    Eating and speech problems in oral and pharyngeal cancer survivors – Associations with treatment-related side-effects and time since diagnosis
    Special Care in Dentistry: managing special patients, settings, and situations 2022 ARKIV / DOI
  • Rabeia Almahmoudi, Abdelhakim Salem, Elin Synnøve Hadler-Olsen, Gunbjørg Svineng, Tuula Salo, Ahmed Al-Samadi :
    The effect of interleukin-17F on vasculogenic mimicry in oral tongue squamous cell carcinoma
    Cancer Science 2021 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Birgitta Jönsson :
    Oral health and use of dental services in different stages of adulthood in Norway: a cross sectional study
    BMC Oral Health 2021 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen :
    Erfaringer med økonomiske støtteordninger for tannbehandling hos personer som er behandlet for hode-halskreft
    Den norske tannlegeforenings tidende 2021 ARKIV
  • Synnøve Norvoll Magnussen, Jimita Prashant Toraskar, Elin Synnøve Hadler-Olsen, Tonje S. Steigedal, Gunbjørg Svineng :
    Nephronectin as a matrix effector in cancer
    Cancers 25. February 2021 ARKIV / DOI
  • Anna Maria Wirsing, Inger-Heidi Bjerkli, Sonja Eriksson Steigen, Oddveig G Rikardsen, Synnøve Norvoll Magnussen, Beate Hegge et al.:
    Validation of Selected Head and Neck Cancer Prognostic Markers from the Pathology Atlas in an Oral Tongue Cancer Cohort
    Cancers 2021 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Elizabeth Thon, Gro Eirin Holde, Birgitta Jönsson, Nils Oscarson, Anders Tillberg :
    Temporomandibular disorders in an adult population in northern Norway: A cross-sectional study
    Clinical and Experimental Dental Research 2021 ARKIV / DOI
  • Sini Karinen, Krista Juurikka, Roosa Hujanen, Wafa Whabi, Elin Synnøve Hadler-Olsen, Gunbjørg Svineng et al.:
    Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?
    Oncogenesis 2021 ARKIV / DOI
  • Sonja Eriksson Steigen, Tine Merete Søland, Elisabeth Sivy Nginamau, Helene Laurvik, Daniela Elena Costea, Anne Christine Johannessen et al.:
    Grading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better?
    Journal of Oral Pathology & Medicine 2020 ARKIV / DOI
  • Inger-Heidi Bjerkli, Olav Jetlund, Gunnhild Karevold, Åsa Karlsdottir, Ellen A. Andreassen Jaatun, Lars Uhlin-Hansen et al.:
    Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study
    PLOS ONE 2020 ARKIV / DOI
  • Synnøve Norvoll Magnussen, Jimita Prashant Toraskar, Imola Wilhelm, Janos Hasko, Stine Figenschau, Judit Molnar et al.:
    Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains
    Scientific Reports 2020 ARKIV / DOI
  • Inger-Heidi Bjerkli, Elin Synnøve Hadler-Olsen, Elisabeth Sivy Nginamau, Helene Laurvik, Tine Merete Søland, Daniela Elena Costea et al.:
    A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer
    Virchows Archiv 30. June 2020 ARKIV / DOI
  • Inger-Heidi Bjerkli, Helene Laurvik, Elisabeth Sivy Nginamau, Tine Merete Søland, Daniela Elena Costea, Håkon Hov et al.:
    Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report
    PLOS ONE 25. September 2020 ARKIV / DOI
  • Meri Sieviläinen, Anna Maria Wirsing, Aini Hyytiäinen, Rabeia Almahmoudi, Priscila Rodrigues, Inger-Heidi Bjerkli et al.:
    Evaluation challenges in the validation of B7-H3 as oral tongue cancer prognosticator
    Head and Neck Pathology 21. September 2020 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Jan-Olof Winberg :
    Method for Determining Gelatinolytic Activity in Tissue Extracts: Real-Time Gelatin Zymography.
    Methods in molecular biology 2019 ARKIV / DOI
  • Mark Owyong, Jonathan Chou, Renske van den Bijgaart, Niwen Kong, Gizem Efe, Carrie Maynard et al.:
    MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy
    Life Science Alliance (LSA) 2019 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Jan-Olof Winberg :
    Method for Determining Gelatinolytic Activity in Tissue: In Situ Gelatin Zymography
    Methods in molecular biology 2019 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Anna Maria Wirsing :
    Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis
    British Journal of Cancer 2019 ARKIV / DOI
  • Anna Maria Wirsing, Ida Korsnes Ervik, Marit Seppola, Lars Uhlin-Hansen, Sonja Eriksson Steigen, Elin Synnøve Hadler-Olsen :
    Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carcinoma
    Modern Pathology 2018 ARKIV / DOI
  • Steinar Risnes, Qalbi Khan, Elin Synnøve Hadler-Olsen, Amer Sehic :
    Tooth identification puzzle: A method of teaching and learning tooth morphology
    European journal of dental education 2018 DOI
  • Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane de Albuquerque Cavalcanti Jacobsen, Bente Mortensen et al.:
    Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion
    BMC Cancer 2017 ARKIV / DOI
  • Kjersti Sellæg, Ruth Schwienbacher, Anna Maria Wirsing, Anna Engan Aamodt, Elin Synnøve Hadler-Olsen, Gerd Berge et al.:
    The spatiotemporal immune profile during mouse oral carcinogenesis
    2023
  • Elin Synnøve Hadler-Olsen :
    Munn- og halskreft - hva forventes av allmenntannlegen?
    2023
  • Elin Synnøve Hadler-Olsen :
    Pasienten med munn- og halskreft
    2023
  • Synnøve Magnussen, Gerd Berge, Ruth Schwienbacher, Anna Maria Wirsing, Elin Synnøve Hadler-Olsen :
    The spatiotemporal immune profile during mouse oral carcinogenesis
    Molecular Oncology 2023 DOI
  • Ruth Schwienbacher, Anna Engan Aamodt, Anna Maria Wirsing, Gerd Berge, Elin Synnøve Hadler-Olsen, Synnøve Magnussen :
    The spatiotemporal immune profile during mouse oral carcinogenesis - high-endothelial venules develop during early stages - and accumulate in late-stage disease
    2023
  • Ruth Schwienbacher, Anna Engan Aamodt, Anna Maria Wirsing, Gerd Berge, Elin Synnøve Hadler-Olsen, Synnøve Magnussen :
    The spatiotemporal immune profile during mouse oral carcinogenesis - high-endothelial venules develop during early stages - and accumulate in late-stage disease
    2023
  • kristina garfjell Kantola, Elin Synnøve Hadler-Olsen, Jan Are Kolset Johnsen, Rolf Wynn :
    Oral health in Norwegian psychiatric inpatients
    2023
  • Elin Synnøve Hadler-Olsen :
    Seneffekter, tannhelse, økonomi og livskvalitet
    2022
  • Rolf Wynn, kristina garfjell Kantola, Elin Synnøve Hadler-Olsen, Jan-Are Kolset Johnsen :
    Oral health in inpatients with psychiatric or substance use disorders
    International Journal of Integrated Care (IJIC) 2022 DOI
  • Elin Synnøve Hadler-Olsen, Bondø Therese, Andreas Jörn Schmalfuss, Veronica Turange, Anne Sofie Rønnfeldt, Lene Marita Steinvik :
    Unge drar ikke til tannlegen: – Kvier seg for regninga
    05. July 2021 FULLTEKST
  • Kristina Garfjell Kantola, Jan-Are Kolset Johnsen, Elin Synnøve Hadler-Olsen, Rolf Wynn :
    DENTAL COMORBIDITY IN A PSYCHIATRIC INPATIENT POPULATION
    2021
  • Elin Synnøve Hadler-Olsen, Therese Bondø, Lene Marita Steinvik :
    Forsker på tannhelse blant unge
    06. July 2021
  • Kristina Garfjell Kantola, Elin Synnøve Hadler-Olsen, Jan-Are Kolset Johnsen, Rolf Wynn :
    ORAL HEALTH IN INPATIENTS WITH PSYCHIATRIC OR SUBSTANCE USE DISORDERS
    2021
  • Vibeke Hervik Bull, Elin Synnøve Hadler-Olsen, Ellen Berggreen, Astrid Jullumstrø Feuerherm, Vibeke Elise Ansteinsson :
    De odontologiske kompetansesentrene satser på forskning på sårbare grupper for å redusere ulikheter i oral helse
    Den norske tannlegeforenings tidende 2021
  • Elin Synnøve Hadler-Olsen, Marit Aaby Vebenstad :
    Sårbare pasienter må dekke egen tannbehandling
    08. December 2021 FULLTEKST
  • Abdelhakim Salem, Elin Synnøve Hadler-Olsen, Ahmed Al-Samadi :
    Editorial: Angiogenesis and Angiogenesis Inhibitors in Oral Cancer
    Frontiers in Oral Health 2021 FULLTEKST / DOI
  • Elin Synnøve Hadler-Olsen, Anna Maria Wirsing :
    Reply to ‘Comment on “Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis”’
    British Journal of Cancer 2019 DOI
  • Elin Synnøve Hadler-Olsen :
    Forsker vil ha rettferdighet for munn- og halskreftpasienter
    13. September 2019 FULLTEKST
  • Synnøve Magnussen, Jimita Prashant Toraskar, Imola Wilhelm, Janos Hasko, Stine Figenschau, Judith Molnar et al.:
    Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains
    2018
  • Elin Synnøve Hadler-Olsen, Are Rydland :
    Når behandlingsskader blir problemet
    Morgenbladet 17. October 2018
  • Elin Synnøve Hadler-Olsen :
    High Endothelial venules and inflammation in oral squamous cell carcinoma
    2018

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    Research interests

    Oral cancer

    Tumor biology

    Oral health

    My interest and research in oral cancer ranges from projects focusing on tumor biology/immunology and prognostic markers to quality of life, rehabilitation and follow-up of treatment related side effects. I also have research projects on oral health and the use of dental services both in the general population and among vulnerable groups.

    Teaching

    Oral anatomy and oral pathology


    Member of research group





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