Christopher Frøhlich
Postdoc. Research Fellow, Biomolecular and Structural Chemistry
Yuwen Jia,
Barbara Schroeder,
Yvonne Pfeifer,
Christopher Frøhlich,
Lihua Deng,
Christoph Arkona
et al.:
Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-β-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems
Journal of Medicinal Chemistry 2023 DOI
Christopher Frøhlich,
John Z Chen,
Sevan Gholipour,
Ayse N Erdogan,
Nobuhiko Tokuriki
:
Evolution of β-lactamases and enzyme promiscuity
Christopher Frøhlich,
João Alves Gama,
Klaus Harms,
Viivi H. A. Hirvonen,
Bjarte Aarmo Lund,
Marc W. van der Kamp
et al.:
Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations
Zeeshan Muhammad,
Susann Skagseth,
Marc Boomgaren,
Sundus Akhter,
Christopher Frøhlich,
Aya Ismael
et al.:
Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases
Christopher Frøhlich,
Vidar Sørum,
Sandra Huber,
Ørjan Samuelsen,
Fanny Berglund,
Erik Kristiansson
et al.:
Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1
Ørjan Samuelsen,
Ove Alexander Høgmoen Åstrand,
Christopher Frøhlich,
Adam Heikal,
Susann Skagseth,
Trine Josefine Olsen Carlsen
et al.:
ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo
Christopher Frøhlich,
Vidar Sørum,
Ane Molden Thomassen,
Pål Jarle Johnsen,
Hanna-Kirsti S. Leiros,
Ørjan Samuelsen
:
OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs
Anthony Prandina,
Sylvie Radix,
Marc Le Borgne,
Lars Petter Jordheim,
Zineb Bousfiha,
Christopher Fröhlich
et al.:
Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors
Geir Kildahl-Andersen,
Christian Schnaars,
Anthony Prandina,
Sylvie Radix,
Marc Le Borgne,
Lars Petter Jordheim
et al.:
Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors
MedChemComm 2019 DOI
Christian Schnaars,
Geir kildahl-Andersen,
Anthony Prandina,
Roya Popal,
Sylvie Radix,
Marc Le Borgne
et al.:
Synthesis and preclinical evaluation of TPA-based zinc chelators as metallo-β-lactamase inhibitors
ACS Infectious Diseases 2018 DOI
Christopher Frøhlich,
Vidar Sørum,
Nobuhiko Tokuriki,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Evolution of β-lactamase-mediated cefiderocol resistance
Øyvind Myrvoll Lorentzen,
Christopher Fröhlich,
Anne Sofie Haukefer,
Sören Abel,
Pål Jarle Johnsen
:
Evolution of Vibrio cholerae biofilms
2023
Christopher Frøhlich,
Hanna-Kirsti S. Leiros
:
Vi må kanskje ta antibiotika hyppigere
Christopher Frøhlich,
Vidar Sørum,
Nobuhiko Tokuriki,
Ørjan Samuelsen
:
Evolution of ß-lactamase mediated cefiderocol resistance
2022
Christopher Frøhlich,
Adrian H. Bunzel,
Marc W. Van Der Kamp,
Adrian J. Mulholland,
Hanna-Kirsti Schrøder Leiros,
Pål Jarle Johnsen
et al.:
Positive epistasis drives the molecular evolution of the carbapenemase OXA-48
2022
Christopher Frøhlich,
Hanna-Kirsti S. Leiros,
Charlotte Miton,
Nobuhiko Tokuriki
:
Ceftazidime drives the evolution of the carbapenemase OXA-48
2020
Christopher Frøhlich,
Hanna-Kirsti S. Leiros,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase
2019
Christopher Frøhlich,
Pål Jarle Johnsen,
Hanna-Kirsti Schrøder Leiros,
Ørjan Samuelsen
:
Evolution of OXA-48 under sub-MIC conditions
2019
Christopher Frøhlich,
Vidar Sørum,
Hanna-Kirsti S. Leiros,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off
2018
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Research interests
X-ray crystallography
Enzymes: expression, purification, kinetics
Inhibitor development and screening (cell and enzyme based)
Resistance development
Evolution
Teaching
KJE-3402 - Protein Structure
F1301- Farmasøytisk kjemi
CV
2014-2016 Master of Science in Analytical Chemistry
2011-2014 Bachelor of Science in Pharmaceutical Chemistry
2009-2016 Chemical Lab Technician at Merck Sharp and Dohme (Cologne)