My previous work
I worked on the evaluation of the impact of long-term amoxicillin administration on the human resistome using functional metagenomics
Five novel genes were identified at which one of them could resist the PenicillinG at a MIC higher than the breakpoint reported by EUCAST by 300 times.
Current work
Funded by Helse Nord RHF
This is an observational, longitudinal study that included 31 probiotic-supplemented extremely preterm infants, 35 very preterm infants not given probiotics, and 10 healthy full-term control infants. This study will identify the impact of probiotics and antibiotic therapy on infants gut microbiota, resistome, and mobilome.
- Second project (Meta-analysis study)
This study represents a comprehensive meta-analysis incorporating data from 14 previously published cohort studies, with the objective of elucidating the influence of various factors - including antibiotic exposure, gestational age, mode of delivery, type of milk, and geographic location - on the gut microbiota, resistome, and mobilome of infants. Furthermore, this research endeavors to identify the specific bacterial species that may predominantly act as reservoirs for antibiotic resistance genes, thereby contributing to our understanding of microbial ecology and antibiotic resistance dissemination.
This is a randomized clinical trial co-led by the Pediatric Research group in Tromsø (UiT / UNN), which investigates the impact of probiotic therapy in Tanzanian infants and its potential to prevent infections by ESBL-producing Enterobacterales.
This is a pilot study of newborns with suspected signs of infection during the 1st week of life leading to antibiotic therapy. The purpose of the study is to report changes in fecal microbial composition in relation to antibiotic usage and integrate the result with a metabolomics study.
