Projects

180 °N (fka Coastal Cooperation)

BrainSTORM: PET in Targeted Brain Theranostics and Education

Cancer-Associated Fibroblasts Role in Lung Tumor Responses to Radiotherapy and Immunotherapy

Radiotherapy to Enhance Response Rates to Immunotherapies

SECURE - Novel Marine Resources for Food Security and Food Safety


180 °N

f.k.a. Coastal Cooperation (Kystsamarbeid)

The 180 °N project is funded by Tromsø Research Foundation and Trond Mohn Foundation, both based on donations from Trond Mohn.

 

The 180 °N project is a new national research collaboration led by Universities and University Hospitals in Tromsø, Trondheim and Bergen. Stavanger University Hospital also participates as a partner in one of the projects. The 180 °N project aims to develop methods for various cancer diseases and neurological disorders, and to improve patient stratification and personalized treatment. The research program starts in 2019 and will last until 2024.

Towards the collaborative goals, the Bergen project focuses on the development of radioactive tracers, Tromsø on preclinical testing, and Trondheim on clinical trials. A close cooperation network in the fields of tracer development, pharmacology, chemistry, (radiation) oncology, (radiation) biology, nuclear medicine, immunology, drug development and machine learning are established. State-of-the-art imaging diagnostic equipment is also funded by private gifts from Trond Mohn to the University Hospitals in the three cities. This allows method and routine transfer between institutions, and that the projects can reinforce each other with knowledge and data from their focus fields.

For information about the projects and contacts at Bergen and Trondheim please refer to the 180N-Trondheim website and the post of Tromsø Research Foundation.

Tromsø project:
Targeting tumor microenvironment
Boosting PET-based diagnostics and therapies

The project in Tromsø, led by Assoc. Prof. Rune Sundset, will test the innovative nuclear medicines in vitro and in vivo at the Preclinical Core Facility with the advanced infrastructure in nuclear medicine and radiation biology. Moreover, in order to improve quantification and to monitor therapy-induced changes, novel machine learning methods will be developed and applied to the imaging data. This will be further developed as a clinical tool to facilitate treatment selection and monitoring in routine clinical application. The Coastal Cooperation, with its unique infrastructure and merged experience, will push forward the development of imaging agents, radiotheranostics and patient-specific nuclear therapies.

  

Work packages (WP) of the Coastal Cooperation Tromsø project

WP 1: Immune-PET and lung cancer
PI: Inigo Zubiavrre Martinez and Turid Hellevik

WP 2: Radionuclide targeted therapy and imaging in Glioblastoma
PI: Mathias Kranz and Rune Sundset

WP3: Phagocyte targeting in breast cancer
PI: Sjoerd Hak and Natasa Skalko-Basnet

WP4: Advancing oncological PET imaging using machine learning
PI: Stian Normann Anfinsen and Robert Jenssen

PhD and postdoctoral projects

Please check the 180 oN website.


BrainSTORM: PET in Targeted Brain Theranostics and Education 

Brain theranostics holds tremendous promise for treatment of brain disease, involving design and development of molecular probes for imaging, monitoring and therapy. However, significant challenges remain, such as blood-brain barrier (BBB) permeability, targeted and controlled delivery to specific brain regions as well as early disease diagnosis. The BrainSTORM project aims to address these challenges via multidisciplinary approaches to personalized precision medicine in the areas of Alzheimer ́s disease, depression and brain cancer. The Positron Emission Tomography (PET) Imaging Center in Tromsø opened in 2018 as a state-of-the-art facility for clinical and preclinical PET/CT, PET/MR and SPECT/CT imaging as well as base for the generation of radioactive isotopes and molecules. The co-localization with established UiT research environments in medicine, chemistry, physics, pharmaceutical sciences, biology and science education enable us to develop cutting-edge brain theranostics for personalized precision medicine and an integrated unique educational program. Objectives of the BrainSTORM project include:
  1. Develop PET/SPECT-radiotracers and nanoparticle delivery systems selectively targeting brain receptors central to Alzheimer ́s disease, depression and cancer.
  2. Apply radiotracer systems to cutting-edge theranostics (therapy and diagnostics) and basic brain function studies on animal models.
  3. Advance secondary and tertiary education within interdisciplinary science in health technology and its use in research, treatment and diagnosis of brain diseases.
The BrainSTORM project is funded by the UiT Strategic Areas (Tematiske satsninger) program and led by Assoc. Prof. Jørn Hedløy Hansen (also see the Hansen research group website). The project starts in 2019 and will last until 2022.

Work packages (WP) of the BrainSTORM project

WP1 : Modelling and in silico screening
PI: Ingebrigt Sylte

WP2: Chemical synthesis and radiolabeling methodology
PI: Jørn Hedløy Hansen

WP3: Nanotheranostics and nanomedicine
PI: Natasa Skalko-Basnet

WP4: Seal brain hypoxia mechanism
PI: Lars Folkow

PhD and postdoctoral projects

Please check back later.


Cancer-Associated Fibroblasts Role in Lung Tumor Responses to Radiotherapy and Immunotherapy

In this project we aim at unveiling responses of tumor stromal fibroblasts to ionizing radiation, with special emphasize on tumor-growth regulatory effects and immune/inflammatory responses. This project is funded by Helse Nord and Aakre Erna Og Olav Stiftelse, and led by Prof. Inigo Zubiavrre Martinez and Researcher Turid Hellevik.




Radiotherapy to Enhance Response Rates to Immunotherapies

Evidences has revealed that local radiotherapy (RT), applied to patients in specific forms, can turn tumors into in situ vaccines. However, systematic studies at the pre-clinical phase on optimal timing and delivery of RT that could synergize with immunotherapies are still inadequate. In this project we propose to study systematically, in pre-clinical mouse models, the local and systemic immuno-responses elicited by RT applied in different schemes, in order to delineate optimal RT regimens for combinatory immunotherapeutic interventions. This project aims to achieve personalized immunization and enhance responses to immunotherapies by means of radiotherapy.

This project is funded by Helse Nord and Norwegian Cancer Society, and led by Prof. Inigo Zubiavrre Martinez and Researcher Turid Hellevik.


SECURE - Novel Marine Resources for Food Security and Food Safety

SECURE overall objectives:
To develop knowledge enabling sustainable food security and safety by a multidisciplinary approach based on novel marine low trophic level resources, cardiometabolic health and legal framework.

The novel low-trophic Arctic raw materials selected for this project include microalgae, calanus and sea cucumber, all novel resources with emerging industries. Several interdisciplinary work packages (WP) will conduct research on the legal framework regarding harvesting of new species, composition of nutrients and contaminants in these raw materials, their effects on the oral and gut microbiome, on cardiometabolic diseases and atherosclerosis and the link between gut microbiota and atherosclerosis. PET imaging will provide an important novel non-invasive tool to study the development of atherosclerotic plaque and enhance the accuracy of atherosclerotic lesion characterization. The knowledge will be ranked against traditional seafood items to enable targeted dietary advice. A stakeholder from the industry will also provide knowledge and experience with regulations and contribute with feedback throughout the project.

This project is funded by UiT Tematiske Satsninger. The Work Package 2.1 "Small animal radionuclide preclinical imaging in atherosclerosis" is led by Assoc. Prof. Rune Sundset and Assoc. Prof. Karl-Erik Eilertsen.




 


Page administrator: Yu-Fen Chang

 

Contact
Group Leader
Rune Sundset, Assoc. Prof., MD, PhD
Visit us
Hansine Hansens veg 82, Tromsø
UiT The Arctic University of Norway
Colocated with
PET Imaging Center
The University Hospital of North Norway (UNN)
Mailing address
Nuclear Medicine and Radiation Biology Research Group
Institute of Clinical Medicine
Faculty of Health Sciences
UiT The Arctic University of Norway 
9037 Tromsø
Norway